000117689 001__ 117689
000117689 005__ 20240319081007.0
000117689 0247_ $$2doi$$a10.1093/ijnp/pyac023
000117689 0248_ $$2sideral$$a129362
000117689 037__ $$aART-2022-129362
000117689 041__ $$aeng
000117689 100__ $$aHidalgo-Figueroa, Maria
000117689 245__ $$aThe Influence of Oxytocin and Prolactin During a First Episode of Psychosis: The Implication of Sex Differences, Clinical Features, and Cognitive Performance
000117689 260__ $$c2022
000117689 5060_ $$aAccess copy available to the general public$$fUnrestricted
000117689 5203_ $$aBackground Approximately 3% of the population suffers a first episode of psychosis (FEP), and a high percentage of these patients subsequently relapse. Because the clinical course following a FEP is hard to predict, it is of interest to identify cognitive and biological markers that will help improve the diagnosis, treatment, and outcome of such events and to define new therapeutic targets. Here we analyzed the plasma oxytocin and prolactin levels during an FEP, assessing their correlation with clinical and cognitive features. Methods The oxytocin and prolactin in plasma was measured in 120 FEP patients and 106 healthy controls, all of whom were subjected to a clinical and neuropsychological assessment. Most patients were under antipsychotics. Statistical analyses aimed to identify factors associated with the FEP and to search for associations between the variables. This study is preliminary and exploratory because the P-values were not corrected for multiple comparisons. Results FEP patients had less oxytocin, more prolactin, and a poor premorbid IQ, and they performed worse in sustained attention. Male patients with higher prolactin levels experienced more severe psychotic symptoms and required higher doses of antipsychotics. Low oxytocin was associated with poor sustained attention in women, whereas low oxytocin and high prolactin in men correlated with better performance in sustained attention. Conclusion Low oxytocin, high prolactin, and poor premorbid IQ and sustained attention are factors associated with an FEP, representing potential therapeutic targets in these patients. These biological factors and cognitive domains might play an important role during a FEP, which could help us to develop new strategies that improve the outcomes of this disorder and that should perhaps be gender specific.
000117689 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII-FIS-FEDER/PI19-00766
000117689 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/
000117689 590__ $$a4.8$$b2022
000117689 592__ $$a1.406$$b2022
000117689 591__ $$aPHARMACOLOGY & PHARMACY$$b65 / 278 = 0.234$$c2022$$dQ1$$eT1
000117689 593__ $$aPharmacology$$c2022$$dQ1
000117689 591__ $$aCLINICAL NEUROLOGY$$b49 / 212 = 0.231$$c2022$$dQ1$$eT1
000117689 593__ $$aPsychiatry and Mental Health$$c2022$$dQ1
000117689 591__ $$aPSYCHIATRY$$b50 / 154 = 0.325$$c2022$$dQ2$$eT1
000117689 593__ $$aPharmacology (medical)$$c2022$$dQ1
000117689 591__ $$aNEUROSCIENCES$$b80 / 272 = 0.294$$c2022$$dQ2$$eT1
000117689 594__ $$a7.8$$b2022
000117689 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000117689 700__ $$aSalazar, Alejandro
000117689 700__ $$aRomero-Lopez-Alberca, Cristina
000117689 700__ $$aMacDowell, Karina S.
000117689 700__ $$aGarcia-Bueno, Borja
000117689 700__ $$aBioque, Miquel
000117689 700__ $$aBernardo, Miquel
000117689 700__ $$aParellada, Mara
000117689 700__ $$aGonzalez-Pinto, Ana
000117689 700__ $$aGarcia Portilla, Maria Paz
000117689 700__ $$0(orcid)0000-0002-9098-655X$$aLobo Satué, Antonio$$uUniversidad de Zaragoza
000117689 700__ $$aRodriguez-Jimenez, Roberto
000117689 700__ $$aBerrocoso, Esther
000117689 700__ $$aLeza, Juan C.
000117689 7102_ $$11007$$2745$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Psiquiatría
000117689 773__ $$g25, 8 (2022), 666–677$$pInt. j. neuropsychopharmacol.$$tINTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY$$x1461-1457
000117689 8564_ $$s1420995$$uhttps://zaguan.unizar.es/record/117689/files/texto_completo.pdf$$yVersión publicada
000117689 8564_ $$s2657042$$uhttps://zaguan.unizar.es/record/117689/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000117689 909CO $$ooai:zaguan.unizar.es:117689$$particulos$$pdriver
000117689 951__ $$a2024-03-18-14:43:16
000117689 980__ $$aARTICLE