000117691 001__ 117691 000117691 005__ 20240319081007.0 000117691 0247_ $$2doi$$a10.3389/fnut.2022.821548 000117691 0248_ $$2sideral$$a129181 000117691 037__ $$aART-2022-129181 000117691 041__ $$aeng 000117691 100__ $$aLlorente-Cantarero, F. 000117691 245__ $$aPrepubertal Children With Metabolically Healthy Obesity or Overweight Are More Active Than Their Metabolically Unhealthy Peers Irrespective of Weight Status: GENOBOX Study 000117691 260__ $$c2022 000117691 5060_ $$aAccess copy available to the general public$$fUnrestricted 000117691 5203_ $$aBackground and Aim: The association of a metabolically healthy status with the practice of physical activity (PA) remains unclear. Sedentarism and low PA have been linked to increased cardiometabolic risk. The aim of this study was to evaluate the PA levels in metabolically healthy (MH) or unhealthy (MU) prepubertal children with or without overweight/obesity. Methods: A total 275 children (144 boys) with 9 ± 2 years old were selected for the GENOBOX study. PA times and intensities were evaluated by accelerometry, and anthropometry, blood pressure, and blood biochemical markers were analyzed. Children were considered to have normal weight or obesity, and further classified as MH or MU upon fulfillment of the considered metabolic criteria. Results: Classification resulted in 119 MH children (21% with overweight/obesity, referred to as MHO) and 156 MU children (47% with overweight/obesity, referred to as MUO). Regarding metabolic profile, MHO showed lower blood pressure levels, both systolic and diastolic and biochemical markers levels, such as glucose, Homeostatic Model Assessment of Insulin Resistance, triglycerides and higher HDL-c levels than MUO (P < 0.001). In addition, MHO children spent more time in PA of moderate intensity compared with MUO children. In relation to vigorous PA, MH normal weight (MHN) children showed higher levels than MUO children. Considering sex, boys spent more time engaged in moderate, vigorous, and moderate–vigorous (MV) PA than girls, and the number of boys in the MH group was also higher. Conclusion: Prepubertal MHO children are less sedentary, more active, and have better metabolic profiles than their MUO peers. However, all children, especially girls, should increase their PA engagement, both in terms of time and intensity because PA appears to be beneficial for metabolic health status itself. Copyright © 2022 Llorente-Cantarero, Leis, Rupérez, Anguita-Ruiz, Vázquez-Cobela, Flores-Rojas, González-Gil, Aguilera, Moreno, Gil-Campos and Bueno. 000117691 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI051968$$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI11-02042$$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI11-02059$$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI16-00871$$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI16-01205$$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI16-01301$$9info:eu-repo/grantAgreement/ES/ISCIII/i-PFIS-IFI17-00048$$9info:eu-repo/grantAgreement/ES/MEC/FPU16-03653 000117691 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000117691 590__ $$a5.0$$b2022 000117691 592__ $$a0.875$$b2022 000117691 591__ $$aNUTRITION & DIETETICS$$b28 / 87 = 0.322$$c2022$$dQ2$$eT1 000117691 593__ $$aFood Science$$c2022$$dQ1 000117691 593__ $$aNutrition and Dietetics$$c2022$$dQ2 000117691 593__ $$aEndocrinology, Diabetes and Metabolism$$c2022$$dQ2 000117691 594__ $$a3.5$$b2022 000117691 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000117691 700__ $$aLeis, R. 000117691 700__ $$aRupérez, A. I. 000117691 700__ $$aAnguita-Ruiz, A. 000117691 700__ $$aVázquez-Cobela, R. 000117691 700__ $$aFlores-Rojas, K. 000117691 700__ $$aGonzález-Gil, E. M. 000117691 700__ $$aAguilera, C. M. 000117691 700__ $$aMoreno, L. A. 000117691 700__ $$aGil-Campos, M. 000117691 700__ $$0(orcid)0000-0002-0902-387X$$aBueno Lozano, G.$$uUniversidad de Zaragoza 000117691 7102_ $$11011$$2670$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Pediatría 000117691 773__ $$g9 (2022), 821542 [9 pp]$$pFront. Nutr.$$tFrontiers in Nutrition$$x2296-861X 000117691 8564_ $$s688367$$uhttps://zaguan.unizar.es/record/117691/files/texto_completo.pdf$$yVersión publicada 000117691 8564_ $$s2529947$$uhttps://zaguan.unizar.es/record/117691/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000117691 909CO $$ooai:zaguan.unizar.es:117691$$particulos$$pdriver 000117691 951__ $$a2024-03-18-14:47:26 000117691 980__ $$aARTICLE