000117701 001__ 117701
000117701 005__ 20240319081010.0
000117701 0247_ $$2doi$$a10.1038/s41537-022-00215-1
000117701 0248_ $$2sideral$$a129248
000117701 037__ $$aART-2022-129248
000117701 041__ $$aeng
000117701 100__ $$aRodriguez, Natalia
000117701 245__ $$aGene co-expression architecture in peripheral blood in a cohort of remitted first-episode schizophrenia patients
000117701 260__ $$c2022
000117701 5060_ $$aAccess copy available to the general public$$fUnrestricted
000117701 5203_ $$aA better understanding of schizophrenia subtypes is necessary to stratify the patients according to clinical attributes. To explore the genomic architecture of schizophrenia symptomatology, we analyzed blood co-expression modules and their association with clinical data from patients in remission after a first episode of schizophrenia. In total, 91 participants of the 2EPS project were included. Gene expression was assessed using the Clariom S Human Array. Weighted-gene co-expression network analysis (WGCNA) was applied to identify modules of co-expressed genes and to test its correlation with global functioning, clinical symptomatology, and premorbid adjustment. Among the 25 modules identified, six modules were significantly correlated with clinical data. These modules could be clustered in two groups according to their correlation with clinical data. Hub genes in each group showing overlap with risk genes for schizophrenia were enriched in biological processes related to metabolic processes, regulation of gene expression, cellular localization and protein transport, immune processes, and neurotrophin pathways. Our results indicate that modules with significant associations with clinical data showed overlap with gene sets previously identified in differential gene-expression analysis in brain, indicating that peripheral tissues could reveal pathogenic mechanisms. Hub genes involved in these modules revealed multiple signaling pathways previously related to schizophrenia, which may represent the complex interplay in the pathological mechanisms behind the disease. These genes could represent potential targets for the development of peripheral biomarkers underlying illness traits in clinical remission stages after a first episode of schizophrenia.
000117701 536__ $$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII-FEDER/PI14-00612$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII-FEDER/PI11-00325$$9info:eu-repo/grantAgreement/ES/ISCIII/PI08-0208
000117701 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000117701 590__ $$a5.4$$b2022
000117701 592__ $$a1.61$$b2022
000117701 591__ $$aPSYCHIATRY$$b45 / 154 = 0.292$$c2022$$dQ2$$eT1
000117701 593__ $$aBiological Psychiatry$$c2022$$dQ1
000117701 593__ $$aPsychiatry and Mental Health$$c2022$$dQ1
000117701 593__ $$aClinical Psychology$$c2022$$dQ1
000117701 594__ $$a5.3$$b2022
000117701 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000117701 700__ $$aGasso, Patricia
000117701 700__ $$aMartinez-Pinteno, Albert
000117701 700__ $$aSegura, Alex-Gonzalez
000117701 700__ $$aMezquida, Gisela
000117701 700__ $$aMoreno-Izco, Lucia
000117701 700__ $$aGonzalez-Penas, Javier
000117701 700__ $$aZorrilla, Inaki
000117701 700__ $$aMartin, Marta
000117701 700__ $$aRodriguez-Jimenez, Roberto
000117701 700__ $$aCorripio, Iluminada
000117701 700__ $$aSarro, Salvador
000117701 700__ $$aIbanez, Angela
000117701 700__ $$aButjosa, Anna
000117701 700__ $$aContreras, Fernando
000117701 700__ $$aBioque, Miquel
000117701 700__ $$aCuesta, Manuel-Jesus
000117701 700__ $$aParellada, Mara
000117701 700__ $$aGonzalez-Pinto, Ana
000117701 700__ $$aBerrocoso, Esther
000117701 700__ $$aBernardo, Miquel
000117701 700__ $$aMas, Sergi
000117701 700__ $$aSilvia Amoretti, S.
000117701 700__ $$aMoren, Constanza
000117701 700__ $$aStella, Carol
000117701 700__ $$aGurriaran, Xaquin
000117701 700__ $$aAlonso-Solis, Anna
000117701 700__ $$aGrasa, Eva
000117701 700__ $$aFernandez, Jessica
000117701 700__ $$aGonzalez-Ortega, Itxaso
000117701 700__ $$aCasanovas, Francesc
000117701 700__ $$aBulbuena, Antoni
000117701 700__ $$aNunez-Doyle, Agatha
000117701 700__ $$aJimenez-Rodriguez, Olga
000117701 700__ $$aPomarol-Clotet, Edith
000117701 700__ $$aFeria-Raposo, Isabel
000117701 700__ $$aUsall, Judith
000117701 700__ $$aMunoz-Samons, Daniel
000117701 700__ $$aIlundain, Jose L.
000117701 700__ $$aMaria Sanchez-Torres, Ana
000117701 700__ $$aSaiz-Ruiz, Jeronimo
000117701 700__ $$aLopez-Torres, Isabel
000117701 700__ $$aNacher, Juan
000117701 700__ $$0(orcid)0000-0003-2284-7862$$aDe la Camara Izquierdo, Concepcion$$uUniversidad de Zaragoza
000117701 700__ $$aGutierrez, Miguel
000117701 700__ $$aAlejandra Saiz, Pilar
000117701 7102_ $$11007$$2745$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Psiquiatría
000117701 773__ $$g8, 45 (2022), [8 pp]$$pNPJ schizophr.$$tNPJ schizophrenia$$x2334-265X
000117701 8564_ $$s892019$$uhttps://zaguan.unizar.es/record/117701/files/texto_completo.pdf$$yVersión publicada
000117701 8564_ $$s3344553$$uhttps://zaguan.unizar.es/record/117701/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000117701 909CO $$ooai:zaguan.unizar.es:117701$$particulos$$pdriver
000117701 951__ $$a2024-03-18-15:04:08
000117701 980__ $$aARTICLE