000117711 001__ 117711
000117711 005__ 20230519145630.0
000117711 0248_ $$2sideral$$a129110
000117711 037__ $$aART-2021-129110
000117711 041__ $$aspa
000117711 100__ $$0(orcid)0000-0002-1960-407X$$aPueyo Paules, Esther$$uUniversidad de Zaragoza
000117711 245__ $$aModelización matemática y simulación computacional de la variabilidad espacio-temporal en la actividad eléctrica cardíaca
000117711 260__ $$c2021
000117711 5060_ $$aAccess copy available to the general public$$fUnrestricted
000117711 5203_ $$aThe electrical activity of the heart is the result of complex biophysical and biochemical processes occurring at different scales ranging from submicroscopic to macroscopic. The variability arising from these processes has important effects on cardiac function under both physiological and pathological conditions. In this review, mathematical modeling and simulation of cardiac electrical variability at the level of the cell, tissue and whole organ will be reviewed. A set of studies will be presented, which investigate the role that the stochastic gating of ion channels of cardiac cell membranes plays in the generation of electrical voltage variations along time. Also, methodologies for the development, calibration and evaluation of populations of mathematical models able to represent variations in cardiac electrophysiology across space, i.e. among cells, tissues or individuals, will be described. In particular, methods based on state-space representations, dimension reduction techniques and nonlinear adaptive filtering will be presented and their capacity to replicate experimentally measured spatio-temporal variability will be illustrated. The importance of these methodologies will be shown as a means to ascertain the mechanisms underlying variability, to establish the link between variability and cardiac arrhythmias (irregularities in heart beating) and to propose clinical markers for diagnosis, monitoring and treatment of cardiac diseases.
000117711 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FSE/T39-20R-BSICoS group$$9info:eu-repo/grantAgreement/ES/DGA/LMP94_21$$9info:eu-repo/grantAgreement/EUR/ERC-2014-StG-638284$$9info:eu-repo/grantAgreement/ES/MICINN-FEDER/PID2019-105674RB-I00
000117711 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-sa$$uhttp://creativecommons.org/licenses/by-nc-sa/3.0/es/
000117711 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000117711 7102_ $$15008$$2800$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Teoría Señal y Comunicac.
000117711 773__ $$g76 (2021), 7-54$$pRev. Acad. Cienc. Exactas, Fís.-Quím. Nat. Zaragoza$$tRevista de la Academia de Ciencias Exactas, Físico-Químicas y Naturales de Zaragoza$$x0370-3207
000117711 8564_ $$s1413026$$uhttps://zaguan.unizar.es/record/117711/files/texto_completo.pdf$$yVersión publicada
000117711 8564_ $$s1415778$$uhttps://zaguan.unizar.es/record/117711/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000117711 909CO $$ooai:zaguan.unizar.es:117711$$particulos$$pdriver
000117711 951__ $$a2023-05-18-16:20:25
000117711 980__ $$aARTICLE