000117977 001__ 117977
000117977 005__ 20240319081008.0
000117977 0247_ $$2doi$$a10.3390/genes13040632
000117977 0248_ $$2sideral$$a129193
000117977 037__ $$aART-2022-129193
000117977 041__ $$aeng
000117977 100__ $$aLauria, F.
000117977 245__ $$aCirculating miRNAs are associated with inflammation biomarkers in children with overweight and obesity: results of the I.Family Study
000117977 260__ $$c2022
000117977 5060_ $$aAccess copy available to the general public$$fUnrestricted
000117977 5203_ $$aIncreasing data suggest that overnutrition-induced obesity may trigger an inflammatory process in adipose tissue and upturn in the innate immune system. Numerous players have been involved in governing the inflammatory response, including epigenetics. Among epigenetic players, miRNAs are emerging as crucial regulators of immune cell development, immune responses, autoimmunity, and inflammation. In this study, we aimed at identifying the involvement of candidate miRNAs in relation to inflammation-associated biomarkers in a subsample of European children with overweight and obesity participating in the I.Family study. The study sample included individuals with increased adiposity since this condition contributes to the early occurrence of chronic low-grade inflammation. We focused on the acute-phase reagent C-reactive protein (CRP) as the primary outcome and selected cytokines as plausible biomarkers of inflammation. We found that chronic low-grade CRP elevation shows a highly significant association with miR-26b-3p and hsa-miR-576-5p in boys. Furthermore, the association of CRP with hsa-miR-10b-5p and hsa-miR-31-5p is highly significant in girls. We also observed major sex-related associations of candidate miRNAs with selected cytokines. Except for IL-6, a significant association of hsa-miR-26b-3p and hsa-miR-576-5p with TNF-a, IL1-Ra, IL-8, and IL-15 levels was found exclusively in boys. The findings of this exploratory study suggest sex differences in the association of circulating miRNAs with inflammatory response biomarkers, and indicate a possible role of miRNAs among the candidate epigenetic mechanisms related to the process of low-grade inflammation in childhood obesity.
000117977 536__ $$9info:eu-repo/grantAgreement/EC/FP7/266044/EU/Determinants of eating behaviour in European children, adolescents and their parents/I.FAMILY
000117977 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000117977 590__ $$a3.5$$b2022
000117977 592__ $$a0.924$$b2022
000117977 591__ $$aGENETICS & HEREDITY$$b66 / 171 = 0.386$$c2022$$dQ2$$eT2
000117977 593__ $$aGenetics (clinical)$$c2022$$dQ2
000117977 593__ $$aGenetics$$c2022$$dQ2
000117977 594__ $$a5.1$$b2022
000117977 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000117977 700__ $$aIacomino, G.
000117977 700__ $$aRusso, P.
000117977 700__ $$aVenezia, A.
000117977 700__ $$aMarena, P.
000117977 700__ $$aAhrens, W.
000117977 700__ $$aDe Henauw, S.
000117977 700__ $$aEiben, G.
000117977 700__ $$aForaita, R.
000117977 700__ $$aHebestreit, A.
000117977 700__ $$aKourides, Y.
000117977 700__ $$aMolnár, D.
000117977 700__ $$0(orcid)0000-0003-0454-653X$$aMoreno, L. A.$$uUniversidad de Zaragoza
000117977 700__ $$aVeidebaum, T.
000117977 700__ $$aSiani, A.
000117977 700__ $$aI.Family Consortium
000117977 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000117977 773__ $$g13, 4 (2022), 632 [9 pp.]$$pGenes (Basel)$$tGenes$$x2073-4425
000117977 8564_ $$s284947$$uhttps://zaguan.unizar.es/record/117977/files/texto_completo.pdf$$yVersión publicada
000117977 8564_ $$s2764189$$uhttps://zaguan.unizar.es/record/117977/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000117977 909CO $$ooai:zaguan.unizar.es:117977$$particulos$$pdriver
000117977 951__ $$a2024-03-18-14:52:43
000117977 980__ $$aARTICLE