000117979 001__ 117979
000117979 005__ 20240319081008.0
000117979 0247_ $$2doi$$a10.3390/cancers14081983
000117979 0248_ $$2sideral$$a129195
000117979 037__ $$aART-2022-129195
000117979 041__ $$aeng
000117979 100__ $$aAyuso, J. M.
000117979 245__ $$aThe importance of the tumor microenvironment to understand tumor origin, evolution, and treatment response
000117979 260__ $$c2022
000117979 5060_ $$aAccess copy available to the general public$$fUnrestricted
000117979 5203_ $$aDuring the second half of the twentieth century, oncology adopted a tumor-centric approach to cancer treatment, focusing primarily on the tumor cell to identify new therapeutic targets. However, since the 2000s, we have seen a gradual shift in this paradigm with numerous studies highlighting the importance of the tumor microenvironment in tumor progression, patient prognosis, and therapy response. Solid tumors are highly complex systems where numerous cell types and microenvironmental factors are intertwined, potentially affecting tumor evolution, treatment response, and patient outcome. Stromal cells such as fibroblasts and immune cells can stimulate or suppress tumor growth and are currently being used as therapeutic targets in numerous studies and clinical trials...
000117979 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000117979 590__ $$a5.2$$b2022
000117979 592__ $$a1.312$$b2022
000117979 591__ $$aONCOLOGY$$b72 / 241 = 0.299$$c2022$$dQ2$$eT1
000117979 593__ $$aOncology$$c2022$$dQ1
000117979 593__ $$aCancer Research$$c2022$$dQ2
000117979 594__ $$a7.4$$b2022
000117979 655_4 $$ainfo:eu-repo/semantics/other$$vinfo:eu-repo/semantics/publishedVersion
000117979 700__ $$0(orcid)0000-0003-2410-5678$$aOchoa Garrido, I.$$uUniversidad de Zaragoza
000117979 7102_ $$11003$$2443$$aUniversidad de Zaragoza$$bDpto. Anatom.Histolog.Humanas$$cArea Histología
000117979 773__ $$g14, 8 (2022), 1983 [4 pp.]$$pCancers$$tCancers$$x2072-6694
000117979 8564_ $$s205009$$uhttps://zaguan.unizar.es/record/117979/files/texto_completo.pdf$$yVersión publicada
000117979 8564_ $$s2910264$$uhttps://zaguan.unizar.es/record/117979/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000117979 909CO $$ooai:zaguan.unizar.es:117979$$particulos$$pdriver
000117979 951__ $$a2024-03-18-14:53:08
000117979 980__ $$aARTICLE