117979 20240319081008.0 doi 10.3390/cancers14081983 sideral 129195 ART-2022-129195 eng Ayuso, J. M. The importance of the tumor microenvironment to understand tumor origin, evolution, and treatment response 2022 Access copy available to the general public Unrestricted During the second half of the twentieth century, oncology adopted a tumor-centric approach to cancer treatment, focusing primarily on the tumor cell to identify new therapeutic targets. However, since the 2000s, we have seen a gradual shift in this paradigm with numerous studies highlighting the importance of the tumor microenvironment in tumor progression, patient prognosis, and therapy response. Solid tumors are highly complex systems where numerous cell types and microenvironmental factors are intertwined, potentially affecting tumor evolution, treatment response, and patient outcome. Stromal cells such as fibroblasts and immune cells can stimulate or suppress tumor growth and are currently being used as therapeutic targets in numerous studies and clinical trials... info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 5.2 2022 ONCOLOGY 72 / 241 = 0.299 2022 Q2 T1 1.312 2022 Oncology 2022 Q1 Cancer Research 2022 Q2 7.4 2022 info:eu-repo/semantics/other info:eu-repo/semantics/publishedVersion Ochoa Garrido, I. Universidad de Zaragoza (orcid)0000-0003-2410-5678 1003 443 Universidad de Zaragoza Dpto. Anatom.Histolog.Humanas Area Histología 14, 8 (2022), 1983 [4 pp.] Cancers Cancers 2072-6694 205009 http://zaguan.unizar.es/record/117979/files/texto_completo.pdf Versión publicada 2910264 http://zaguan.unizar.es/record/117979/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:117979 articulos driver 2024-03-18-14:53:08 ARTICLE