118002 20240319081026.0 doi 10.3390/jpm12050658 sideral 129133 ART-2022-129133 eng Chaure-Pardos, Armando Universidad de Zaragoza Effectiveness of Statins for Primary Prevention of Cardiovascular Disease in Low- and Medium-Risk Males: A Causal Inference Approach with Observational Data 2022 Access copy available to the general public Unrestricted In this study, we analyzed the effectiveness of statin therapy for the primary prevention of cardiovascular disease (CVD) in low- and medium-risk patients. Using observational data, we estimated effectiveness by emulating a hypothetical randomized clinical trial comparing statin initiators with statin non-initiators. Two approaches were used to adjust for potential confounding factors: matching and inverse probability weighting in marginal structural models. The estimates of effectiveness were obtained by intention-to-treat and per-protocol analysis. The intention-to-treat analysis revealed an absolute risk reduction of 7.2 (95% confidence interval (CI95%), −6.6–21.0) events per 1000 subjects treated for 5 years in the matched design, and 2.2 (CI95%, −3.9–8.2) in the marginal structural model. The per-protocol analysis revealed an absolute risk reduction of 16.7 (CI95%, −3.0–36) events per 1000 subjects treated for 5 years in the matched design and 5.8 (CI95%, 0.3–11.4) in the marginal structural model. The indication for statin treatment for primary prevention in individuals with low and medium cardiovascular risk appears to be inefficient, but improves with better adherence and in subjectvs with higher risk. info:eu-repo/grantAgreement/ES/ISCIII-FEDER-FIS/PI17-01704 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 3.4 2022 MEDICINE, GENERAL & INTERNAL 67 / 169 = 0.396 2022 Q2 T2 HEALTH CARE SCIENCES & SERVICES 42 / 106 = 0.396 2022 Q2 T2 0.665 2022 Medicine (miscellaneous) 2022 Q2 2.6 2022 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Aguilar-Palacio, Isabel Universidad de Zaragoza (orcid)0000-0001-7293-701X Rabanaque, Mª José Universidad de Zaragoza (orcid)0000-0002-6671-5661 Lallana, Mª Jesús (orcid)0000-0001-7587-9716 Maldonado, Lina Universidad de Zaragoza (orcid)0000-0003-1647-3462 Castel-Feced, Sara Universidad de Zaragoza (orcid)0000-0002-5064-3763 Librero, Julián (orcid)0000-0002-4859-9054 Casasnovas, José Antonio Universidad de Zaragoza (orcid)0000-0002-9887-2629 Malo, Sara Universidad de Zaragoza (orcid)0000-0002-7194-8275 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 4014 623 Universidad de Zaragoza Dpto. Economía Aplicada Área Métodos Cuant.Econ.Empres 1011 615 Universidad de Zaragoza Dpto. Microb.Ped.Radio.Sal.Pú. Área Medic.Prevent.Salud Públ. 12, 5 (2022), 658 [10 pp.] J. pers. med. Journal of Personalized Medicine 2075-4426 409055 http://zaguan.unizar.es/record/118002/files/texto_completo.pdf Versión publicada 2773841 http://zaguan.unizar.es/record/118002/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:118002 articulos driver 2024-03-18-16:42:08 ARTICLE