118015 20230519145458.0 doi 10.1038/s41598-021-98659-5 sideral 126052 ART-2021-126052 eng Di Mambro, T. A new humanized antibody is effective against pathogenic fungi in vitro 2021 Access copy available to the general public Unrestricted Invasive fungal infections mainly affect patients undergoing transplantation, surgery, neoplastic disease, immunocompromised subjects and premature infants, and cause over 1.5 million deaths every year. The most common fungi isolated in invasive diseases are Candida spp., Cryptococcus spp., and Aspergillus spp. and even if four classes of antifungals are available (Azoles, Echinocandins, Polyenes and Pyrimidine analogues), the side effects of drugs and fungal acquired and innate resistance represent the major hurdles to be overcome. Monoclonal antibodies are powerful tools currently used as diagnostic and therapeutic agents in different clinical contexts but not yet developed for the treatment of invasive fungal infections. In this paper we report the development of the first humanized monoclonal antibody specific for beta-1, 3 glucans, a vital component of several pathogenic fungi. H5K1 has been tested on C. auris, one of the most urgent threats and resulted efficient both alone and in combination with Caspofungin and Amphotericin B showing an enhancement effect. Our results support further preclinical and clinical developments for the use of H5K1 in the treatment of patients in need. info:eu-repo/grantAgreement/ES/DGA/E30-17R info:eu-repo/grantAgreement/ES/DGA/E30-20R info:eu-repo/grantAgreement/ES/MINECO-FEDER/FIS2017-87519-P info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 4.997 2021 MULTIDISCIPLINARY SCIENCES 19 / 74 = 0.257 2021 Q2 T1 1.005 2021 Multidisciplinary 2021 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Vanzolini, T. Bruscolini, P. Universidad de Zaragoza (orcid)0000-0002-5833-8798 Perez-Gaviro, S. Universidad de Zaragoza (orcid)0000-0001-8425-7345 Marra, E. Roscilli, G. Bianchi, M. Fraternale, A. Schiavano, G.F. Canonico, B. Magnani, M. 2004 405 Universidad de Zaragoza Dpto. Física Teórica Área Física Teórica 11, 1 (2021), 19500 [17 pp.] Sci. rep. (Nat. Publ. Group) Scientific reports (Nature Publishing Group) 2045-2322 3730934 http://zaguan.unizar.es/record/118015/files/texto_completo.pdf Versión publicada 2687998 http://zaguan.unizar.es/record/118015/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:118015 articulos driver 2023-05-18-14:53:32 ARTICLE