000118039 001__ 118039
000118039 005__ 20220824113019.0
000118039 0247_ $$2doi$$a10.1371/journal.pone.0051681
000118039 0248_ $$2sideral$$a129727
000118039 037__ $$aART-2012-129727
000118039 041__ $$aeng
000118039 100__ $$0(orcid)0000-0003-2078-8205$$aGarcía, Mar
000118039 245__ $$aStudy of Regulatory T-Cells in Patients with Gastric Malt Lymphoma: Influence on Treatment Response and Outcome
000118039 260__ $$c2012
000118039 5060_ $$aAccess copy available to the general public$$fUnrestricted
000118039 5203_ $$aPurpose
FOXP3+ regulatory T cells (Treg) play an essential role in modulating host responses to tumors and infections. The role of these cells in the pathogenesis of MALT lymphomas remains unknown. The aims of the study were to quantify the number of infiltrating FOXP3+ and CD3+ cells in patients with gastric MALT lymphoma at diagnosis and to study kinetics of these cells and CD20+ tumor cells after treatment and during long-term follow-up.
Methods
FOXP3+, CD3+ and CD20+ cells were analyzed by immunohistochemistry and the number of cells was quantified using a micrometric ocular. Samples of 35 patients with gastric MALT lymphoma at diagnosis and after treatment were included. Diagnostic samples were compared to 19 cases of chronic gastritis and diffuse large B-cell lymphoma (DLBCL) of the stomach.
Results
The median number of FOXP3+ infiltrating cells was higher (27 cells/cm2) in gastric MALT patients than in DLBCL (10 cells; p = 0.162) but similar to chronic gastritis (20 cells; p = 0.605). No characteristic or specific distribution pattern of infiltrating FOXP3+ cells was found. Gastric MALT lymphoma patients responding to bacterial eradication therapy had higher number of FOXP3+ cells at study entry. Kinetics of both infiltrating FOXP3+ cells and tumor CD20+ cells were strongly dependent on the treatment administered.
Discussion
Gastric MALT lymphomas have a number of Treg cells more similar to chronic gastritis than to DLBCL. Patients with higher number of tumor infiltrating FOXP3+ cells at study entry seem to have better response to antibiotics. Kinetics of Treg and tumor cells are influenced by type of treatment
000118039 536__ $$9info:eu-repo/grantAgreement/ES/FIS FEDER/07/0586
000118039 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000118039 590__ $$a3.73$$b2012
000118039 591__ $$aMULTIDISCIPLINARY SCIENCES$$b7 / 57 = 0.123$$c2012$$dQ1$$eT1
000118039 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000118039 700__ $$aBellosillo, Beatriz
000118039 700__ $$aSánchez-González, Blanca
000118039 700__ $$aGarcía-Payarols, Francesc
000118039 700__ $$aSeoane, Agustin
000118039 700__ $$aFerrer, Ana Maria
000118039 700__ $$aGimeno, Eva
000118039 700__ $$aBarranco, Luis Eugenio
000118039 700__ $$aTorner, Ariadna
000118039 700__ $$aSolé, Francesc
000118039 700__ $$aBesses, Carles
000118039 700__ $$aSerrano, Sergi
000118039 700__ $$aSalar, Antonio
000118039 700__ $$aNavarro, Alfons
000118039 773__ $$g7, 12 (2012), e51681$$pPLoS One$$tPLoS ONE$$x1932-6203
000118039 8564_ $$s457320$$uhttps://zaguan.unizar.es/record/118039/files/texto_completo.pdf$$yVersión publicada
000118039 8564_ $$s2952567$$uhttps://zaguan.unizar.es/record/118039/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000118039 909CO $$ooai:zaguan.unizar.es:118039$$particulos$$pdriver
000118039 951__ $$a2022-08-24-09:50:22
000118039 980__ $$aARTICLE