doi:10.1080/19336918.2022.2055520engMerino Casallo, FranciscoGomez Benito, Maria JoseHervas Raluy, SilviaGarcia-Aznar, Jose ManuelUnravelling cell migration: defining movement from the cell surfaceART-2022-128574Cell motility is essential for life and development. Unfortunately, cell migration is also linked to several pathological processes, such as cancer metastasis. Cells’ ability to migrate relies on many actors. Cells change their migratory strategy based on their phenotype and the properties of the surrounding microenvironment. Cell migration is, therefore, an extremely complex phenomenon. Researchers have investigated cell motility for more than a century. Recent discoveries have uncovered some of the mysteries associated with the mechanisms involved in cell migration, such as intracellular signaling and cell mechanics. These findings involve different players, including transmembrane receptors, adhesive complexes, cytoskeletal components , the nucleus, and the extracellular matrix. This review aims to give a global overview of our current understanding of cell migration.2022http://zaguan.unizar.es/record/11804210.1080/19336918.2022.2055520http://zaguan.unizar.es/record/118042oai:zaguan.unizar.es:118042info:eu-repo/grantAgreement/EC/H2020/826494/EU/PRedictive In-silico Multiscale Analytics to support cancer personalized diaGnosis and prognosis, Empowered by imaging biomarkers/PRIMAGEThis project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 826494-PRIMAGEinfo:eu-repo/grantAgreement/ES/MICINN/RTI2018-094494-B-C21info:eu-repo/grantAgreement/ES/MINECO/BES-2016-076291Cell adhesion & migration 16, 1 (2022), 25-64byhttp://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccess