000118050 001__ 118050
000118050 005__ 20220831113013.0
000118050 0247_ $$2doi$$a10.1167/iovs.16-20460
000118050 0248_ $$2sideral$$a98238
000118050 037__ $$aART-2017-98238
000118050 041__ $$aeng
000118050 100__ $$0(orcid)0000-0002-1609-5994$$aSatue, M.
000118050 245__ $$aEvaluation of progressive visual dysfunction and retinal degeneration in patients with parkinson’s disease
000118050 260__ $$c2017
000118050 5060_ $$aAccess copy available to the general public$$fUnrestricted
000118050 5203_ $$aPURPOSE. To quantify changes in visual function parameters and in the retinal nerve fiber layer and macular thickness over a 5-year period in patients with Parkinson’s disease (PD). METHODS. Thirty patients with PD and 30 healthy subjects underwent a complete ophthalmic evaluation, including assessment of visual acuity, contrast sensitivity vision, color vision, and retinal evaluation with spectral-domain optical coherence tomography (SD-OCT). All subjects were reevaluated after 5 years to quantify changes in visual function parameters, the retinal nerve fiber layer, and macular thickness. Association between progressive ophthalmologic changes and disease progression was analyzed. RESULTS. Changes were detected in visual function parameters and retinal nerve fiber layer thickness in patients compared with controls. Greater changes were found during the follow-up in the PD group than healthy subjects in visual acuity, contrast sensitivity, Lanthony color test (P < 0.016), in superotemporal and temporal retinal nerve fiber layer sectors (P < 0.001), and in macular thickness (all sectors except inner superior and inner inferior sectors, P < 0.001). Progressive changes in the retinal nerve fiber layer were associated with disease progression (r = 0.389, P = 0.028). CONCLUSIONS. Progressive visual dysfunction, macular thinning, and axonal loss can be detected in PD. Analysis of the macular thickness and the retinal nerve fiber layer by SD-OCT can be useful for evaluating Parkinson’s disease progression.
000118050 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/CM14-00026$$9info:eu-repo/grantAgreement/ES/ISCIII/PI14-01499
000118050 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000118050 590__ $$a3.388$$b2017
000118050 591__ $$aOPHTHALMOLOGY$$b9 / 59 = 0.153$$c2017$$dQ1$$eT1
000118050 592__ $$a2.058$$b2017
000118050 593__ $$aCellular and Molecular Neuroscience$$c2017$$dQ1
000118050 593__ $$aSensory Systems$$c2017$$dQ1
000118050 593__ $$aOphthalmology$$c2017$$dQ1
000118050 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000118050 700__ $$aRodrigo, M.J.
000118050 700__ $$aObis, J.
000118050 700__ $$0(orcid)0000-0001-9411-5834$$aVilades, E.
000118050 700__ $$aGracia, H.
000118050 700__ $$0(orcid)0000-0002-6591-0801$$aOtin, S.$$uUniversidad de Zaragoza
000118050 700__ $$0(orcid)0000-0002-4316-1635$$aFuertes, M.I.$$uUniversidad de Zaragoza
000118050 700__ $$aAlarcia, R.
000118050 700__ $$aCrespo, J.A.
000118050 700__ $$0(orcid)0000-0002-1402-3129$$aPolo, V.$$uUniversidad de Zaragoza
000118050 700__ $$0(orcid)0000-0002-6745-7668$$aLarrosa, J.M.$$uUniversidad de Zaragoza
000118050 700__ $$0(orcid)0000-0003-2389-8282$$aPablo, L.E.$$uUniversidad de Zaragoza
000118050 700__ $$0(orcid)0000-0001-6258-2489$$aGarcia-Martin, E.$$uUniversidad de Zaragoza
000118050 7102_ $$11004$$2646$$aUniversidad de Zaragoza$$bDpto. Cirugía,Ginecol.Obstetr.$$cÁrea Oftalmología
000118050 7102_ $$12002$$2647$$aUniversidad de Zaragoza$$bDpto. Física Aplicada$$cÁrea Óptica
000118050 773__ $$g58, 2 (2017), 1151-1157$$pInvestig. ophthalmol. vis. sci.$$tInvestigative ophthalmology & visual science$$x0146-0404
000118050 8564_ $$s668598$$uhttps://zaguan.unizar.es/record/118050/files/texto_completo.pdf$$yVersión publicada
000118050 8564_ $$s3176282$$uhttps://zaguan.unizar.es/record/118050/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000118050 909CO $$ooai:zaguan.unizar.es:118050$$particulos$$pdriver
000118050 951__ $$a2022-08-31-09:13:30
000118050 980__ $$aARTICLE