000118073 001__ 118073
000118073 005__ 20240319080953.0
000118073 0247_ $$2doi$$a10.1016/j.jep.2022.115362
000118073 0248_ $$2sideral$$a128714
000118073 037__ $$aART-2022-128714
000118073 041__ $$aeng
000118073 100__ $$aBorgonetti, V.
000118073 245__ $$aYlang-ylang (Cananga odorata (Lam.) Hook. f. & Thomson) essential oil reduced neuropathic-pain and associated anxiety symptoms in mice
000118073 260__ $$c2022
000118073 5060_ $$aAccess copy available to the general public$$fUnrestricted
000118073 5203_ $$aEthnopharmacological relevance: Ylang-ylang essential oil (YEO), obtained from the flowers of the tropical tree Cananga odorata (Lam.) Hook. f. & Thomson (family Annonaceae), has been largely used in the traditional medicine with many uses, including anxiety and altered neuronal states. Neuropathic pain is a chronic pain condition with a high incidence of comorbidities, such as anxiety, depression, and other mood disorders, that drastically affect the patient''s quality of life. The currently available drugs used for the management of neuropathic pain are inadequate due to poor efficacy and tolerability, highlighting the medicinal need of a better pharmacotherapy. Several clinical studies have reported that massage or inhalation with selected essentials oils reduces symptoms associated to pain and anxiety. Aim of the study: The aim of this study was to investigate the analgesic properties of YEO and its efficacy in reducing neuropathy-associated mood alterations. Materials and methods: The analgesic properties were tested in the spared nerve injury (SNI) model using male mice. Anxiolytic, antidepressant, and locomotor properties were also evaluated using behavioural tests. Finally, the YEO mechanism of action was investigated in the spinal cord and hippocampus of neuropathic mice. Results: Oral administration of YEO (30 mg/kg) reduced SNI-induced neuropathic pain and ameliorates pain-related anxiety symptoms that appeared 28 days after surgery. YEO reduced the expression of MAPKs, NOS2, p-p65, markers of neuroinflammation, and promoted normalizing effect on neurotrophin levels (BDNF). Conclusions: YEO induced neuropathic pain relief and ameliorated pain-associated anxiety, representing an interesting candidate for the management of neuropathic pain conditions and pain-related comorbidities. © 2022 The Authors
000118073 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000118073 590__ $$a5.4$$b2022
000118073 592__ $$a0.833$$b2022
000118073 591__ $$aCHEMISTRY, MEDICINAL$$b13 / 60 = 0.217$$c2022$$dQ1$$eT1
000118073 593__ $$aDrug Discovery$$c2022$$dQ1
000118073 591__ $$aINTEGRATIVE & COMPLEMENTARY MEDICINE$$b4 / 28 = 0.143$$c2022$$dQ1$$eT1
000118073 593__ $$aPharmacology$$c2022$$dQ2
000118073 591__ $$aPLANT SCIENCES$$b29 / 239 = 0.121$$c2022$$dQ1$$eT1
000118073 591__ $$aPHARMACOLOGY & PHARMACY$$b50 / 278 = 0.18$$c2022$$dQ1$$eT1
000118073 594__ $$a8.6$$b2022
000118073 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000118073 700__ $$0(orcid)0000-0001-6969-1055$$aLópez, V.
000118073 700__ $$aGaleotti, N.
000118073 773__ $$g294 (2022), 115362 [7 pp.]$$pJ. ethnopharmacol.$$tJOURNAL OF ETHNOPHARMACOLOGY$$x0378-8741
000118073 8564_ $$s2393571$$uhttps://zaguan.unizar.es/record/118073/files/texto_completo.pdf$$yVersión publicada
000118073 8564_ $$s2607481$$uhttps://zaguan.unizar.es/record/118073/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000118073 909CO $$ooai:zaguan.unizar.es:118073$$particulos$$pdriver
000118073 951__ $$a2024-03-18-13:20:17
000118073 980__ $$aARTICLE