000118077 001__ 118077
000118077 005__ 20240319080954.0
000118077 0247_ $$2doi$$a10.1016/j.bmc.2022.116814
000118077 0248_ $$2sideral$$a128718
000118077 037__ $$aART-2022-128718
000118077 041__ $$aeng
000118077 100__ $$aQuintana, M.
000118077 245__ $$aDinuclear silver and gold bisNHC complexes as drug candidates for cancer therapy
000118077 260__ $$c2022
000118077 5060_ $$aAccess copy available to the general public$$fUnrestricted
000118077 5203_ $$aWe report four dinuclear silver(I) and gold(I) complexes containing two different bidentate N-heterocyclic carbene ligands (bisNHC). One of these complexes 4, shows strong and selective anticancer activity against the human ovarian cancer cell line A2780. Mechanistically, 4 enhances the oxidative stress by stimulating reactive oxygen species production and inhibiting the scavenging activity of thioredoxin reductase. Our findings provide evidence that tuning ligand and electronic properties of metal-NHC complexes can modulate their reactivity and selectivity and it may result in potential novel anticancer drugs.
000118077 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FSE/E42-20R$$9info:eu-repo/grantAgreement/ES/MICINN/RTI2018-096323-B-I00
000118077 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000118077 590__ $$a3.5$$b2022
000118077 592__ $$a0.573$$b2022
000118077 591__ $$aCHEMISTRY, ORGANIC$$b12 / 52 = 0.231$$c2022$$dQ1$$eT1
000118077 593__ $$aOrganic Chemistry$$c2022$$dQ2
000118077 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b150 / 285 = 0.526$$c2022$$dQ3$$eT2
000118077 593__ $$aClinical Biochemistry$$c2022$$dQ2
000118077 591__ $$aCHEMISTRY, MEDICINAL$$b32 / 60 = 0.533$$c2022$$dQ3$$eT2
000118077 593__ $$aDrug Discovery$$c2022$$dQ2
000118077 593__ $$aPharmaceutical Science$$c2022$$dQ2
000118077 593__ $$aMolecular Medicine$$c2022$$dQ3
000118077 593__ $$aBiochemistry$$c2022$$dQ3
000118077 593__ $$aMolecular Biology$$c2022$$dQ3
000118077 594__ $$a6.4$$b2022
000118077 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000118077 700__ $$aRodriguez-Rius, A.
000118077 700__ $$0(orcid)0000-0001-6028-5499$$aVellé, A.
000118077 700__ $$aVives, S.
000118077 700__ $$0(orcid)0000-0002-8220-6031$$aSanz Miguel, P.J.$$uUniversidad de Zaragoza
000118077 700__ $$aTriola, G.
000118077 7102_ $$12010$$2760$$aUniversidad de Zaragoza$$bDpto. Química Inorgánica$$cÁrea Química Inorgánica
000118077 773__ $$g67 (2022), 116814 [8 pp.]$$pBioorg. med. chem.$$tBioorganic and Medicinal Chemistry$$x0968-0896
000118077 8564_ $$s2193765$$uhttps://zaguan.unizar.es/record/118077/files/texto_completo.pdf$$yVersión publicada
000118077 8564_ $$s2503065$$uhttps://zaguan.unizar.es/record/118077/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000118077 909CO $$ooai:zaguan.unizar.es:118077$$particulos$$pdriver
000118077 951__ $$a2024-03-18-13:26:30
000118077 980__ $$aARTICLE