118077 20240319080954.0 doi 10.1016/j.bmc.2022.116814 sideral 128718 ART-2022-128718 eng Quintana, M. Dinuclear silver and gold bisNHC complexes as drug candidates for cancer therapy 2022 Access copy available to the general public Unrestricted We report four dinuclear silver(I) and gold(I) complexes containing two different bidentate N-heterocyclic carbene ligands (bisNHC). One of these complexes 4, shows strong and selective anticancer activity against the human ovarian cancer cell line A2780. Mechanistically, 4 enhances the oxidative stress by stimulating reactive oxygen species production and inhibiting the scavenging activity of thioredoxin reductase. Our findings provide evidence that tuning ligand and electronic properties of metal-NHC complexes can modulate their reactivity and selectivity and it may result in potential novel anticancer drugs. info:eu-repo/grantAgreement/ES/DGA-FSE/E42-20R info:eu-repo/grantAgreement/ES/MICINN/RTI2018-096323-B-I00 info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 3.5 2022 CHEMISTRY, ORGANIC 12 / 52 = 0.231 2022 Q1 T1 BIOCHEMISTRY & MOLECULAR BIOLOGY 150 / 285 = 0.526 2022 Q3 T2 CHEMISTRY, MEDICINAL 32 / 60 = 0.533 2022 Q3 T2 0.573 2022 Organic Chemistry 2022 Q2 Clinical Biochemistry 2022 Q2 Drug Discovery 2022 Q2 Pharmaceutical Science 2022 Q2 Molecular Medicine 2022 Q3 Biochemistry 2022 Q3 Molecular Biology 2022 Q3 6.4 2022 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Rodriguez-Rius, A. Vellé, A. (orcid)0000-0001-6028-5499 Vives, S. Sanz Miguel, P.J. Universidad de Zaragoza (orcid)0000-0002-8220-6031 Triola, G. 2010 760 Universidad de Zaragoza Dpto. Química Inorgánica Área Química Inorgánica 67 (2022), 116814 [8 pp.] Bioorg. med. chem. Bioorganic and Medicinal Chemistry 0968-0896 2193765 http://zaguan.unizar.es/record/118077/files/texto_completo.pdf Versión publicada 2503065 http://zaguan.unizar.es/record/118077/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:118077 articulos driver 2024-03-18-13:26:30 ARTICLE