118079 20240319080955.0 doi 10.1016/j.foodcont.2022.109033 sideral 128822 ART-2022-128822 eng Serrano, M.J. (orcid)0000-0003-3850-9833 Antimicrobial residue assessment in 5, 357 commercialized meat samples from the Spain-France cross-border area: A new approach for effective monitoring 2022 Access copy available to the general public Unrestricted Although antimicrobials are valuable allies in animal production, their extended use has led to unexpected threats associated with the emergence and propagation of antimicrobial resistance. Moreover, when withdrawal periods in food-producing animals are not observed, antimicrobial residues can access the food chain, causing direct toxicity, allergies, and/or intestinal microbiota dysbiosis in consumers. Given that Spain and France are the largest meat producers in the EU and also count among the top consumers of meat, our study''s aim was to investigate the presence of antimicrobials in commercialized meat purchased in the Spain-France cross-border area (POCTEFA region). 5, 357 meat samples were collected from different animal species and a variety of different retailer types in Spain (Zaragoza, Bilbao, and Logroño) as well as in France (Toulouse and Perpignan). Meat samples were analysed by a screening method (Explorer®+QuinoScan®), yielding 194 positive samples, which were further evaluated by UPLC-QTOF (Ultra Performance Liquid Chromatography-Quadrupole Time of Flight) for confirmation. Chromatographic analyses found antimicrobial residues in 30 samples, although only 5 of them (0.093% of initial samples) were non-compliant according to the current legislation. Further studies suggested that this mismatch between screening and confirmatory analyses might be due to the presence of biologically active metabolites derived from degradation of antimicrobials that were not identified by the targeted UPLC-QTOF method, but which might play a decisive role in the inhibition of the biological Explorer® test. Although chromatographic techniques detect the marker compounds determined by European and national regulations, and although they are the methods selected for official control of antimicrobials in food, certain unknown metabolites might escape their monitoring. This thus suggests that biological tests are the most adequate ones in terms of ideal consumer health protection. info:eu-repo/grantAgreement/EC/H2020/801586/EU/International Doctoral Programme for Talent Attraction to the Campus of International Excellence of the Ebro Valley/IberusTalent This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 801586-IberusTalent info:eu-repo/grantAgreement/EUR/INTERREG-V-A-POCTEFA/TESTACOS-EFA152/16 info:eu-repo/grantAgreement/EUR/INTERREG-V-A-POCTEFA-2014-2020 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 6.0 2022 FOOD SCIENCE & TECHNOLOGY 24 / 142 = 0.169 2022 Q1 T1 1.057 2022 Food Science 2022 Q1 Biotechnology 2022 Q1 10.6 2022 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Elorduy, J. Zabaleta, I. Istamboulie, G. González-Fandos, E. Bousquet-Mélou, A. Mata, L. Aymard, C. Martínez-Laorden, A. Da Silva-Guedes, J. Lacroix, M. García-Gonzalo, D. Universidad de Zaragoza (orcid)0000-0002-7629-8101 Condón, S. Universidad de Zaragoza (orcid)0000-0002-1902-0648 Abilleira, E. Pagán, R. Universidad de Zaragoza (orcid)0000-0002-0238-6328 2008 780 Universidad de Zaragoza Dpto. Produc.Animal Cienc.Ali. Área Tecnología de Alimentos 138 (2022), 109033 [11 pp.] Food control Food Control 0956-7135 1183856 http://zaguan.unizar.es/record/118079/files/texto_completo.pdf Versión publicada 2282812 http://zaguan.unizar.es/record/118079/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:118079 articulos driver 2024-03-18-13:30:10 ARTICLE