000118122 001__ 118122
000118122 005__ 20240319080944.0
000118122 0247_ $$2doi$$a10.1021/acs.biomac.2c00072
000118122 0248_ $$2sideral$$a129532
000118122 037__ $$aART-2022-129532
000118122 041__ $$aeng
000118122 100__ $$aAimonen, Kukka
000118122 245__ $$aEffect of Surface Modification on the Pulmonary and Systemic Toxicity of Cellulose Nanofibrils
000118122 260__ $$c2022
000118122 5060_ $$aAccess copy available to the general public$$fUnrestricted
000118122 5203_ $$aCellulose nanofibrils (CNFs) have emerged as sustainable options for a wide range of applications. However, the high aspect ratio and biopersistence of CNFs raise concerns about potential health effects. Here, we evaluated the in vivo pulmonary and systemic toxicity of unmodified (U-CNF), carboxymethylated (C-CNF), and TEMPO (2, 2, 6, 6-tetramethyl-piperidin-1-oxyl)-oxidized (T-CNF) CNFs, fibrillated in the same way and administered to mice by repeated (3x) pharyngeal aspiration (14, 28, and 56 mu g/ mouse/aspiration). Toxic effects were assessed up to 90 days after the last administration. Some mice were treated with T-CNF samples spiked with lipopolysaccharide (LPS; 0.02- 50 ng/mouse/aspiration) to assess the role of endotoxin contamination. The CNFs induced an acute infammatory reaction that subsided within 90 days, except for T-CNF. At 90 days post-administration, an increased DNA damage was observed in bronchoalveolar lavage and hepatic cells after exposure to T-CNF and C-CNF, respectively. Besides, LPS contamination dose-dependently increased the hepatic genotoxic effects of T-CNF.
000118122 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000118122 590__ $$a6.2$$b2022
000118122 592__ $$a1.244$$b2022
000118122 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b56 / 285 = 0.196$$c2022$$dQ1$$eT1
000118122 593__ $$aBioengineering$$c2022$$dQ1
000118122 591__ $$aPOLYMER SCIENCE$$b6 / 85 = 0.071$$c2022$$dQ1$$eT1
000118122 593__ $$aPolymers and Plastics$$c2022$$dQ1
000118122 591__ $$aCHEMISTRY, ORGANIC$$b3 / 52 = 0.058$$c2022$$dQ1$$eT1
000118122 593__ $$aMaterials Chemistry$$c2022$$dQ1
000118122 593__ $$aBiomaterials$$c2022$$dQ1
000118122 594__ $$a11.1$$b2022
000118122 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000118122 700__ $$aHartikainen, Mira
000118122 700__ $$aImani, Monireh
000118122 700__ $$aSuhonen, Satu
000118122 700__ $$aVales, Gerard
000118122 700__ $$0(orcid)0000-0002-1946-1187$$aMoreno, Carlos$$uUniversidad de Zaragoza
000118122 700__ $$aSaarelainen, Hanna
000118122 700__ $$aSiivola, Kirsi
000118122 700__ $$aVanhala, Esa
000118122 700__ $$aWolff, Henrik
000118122 700__ $$aRojas, Orlando J.
000118122 700__ $$aNorppa, Hannu
000118122 700__ $$0(orcid)0000-0003-2936-242X$$aCatalan, Julia$$uUniversidad de Zaragoza
000118122 7102_ $$11001$$2420$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Genética
000118122 773__ $$g23, 7 (2022), 2752–2766$$pBiomacromolecules$$tBIOMACROMOLECULES$$x1525-7797
000118122 8564_ $$s15599177$$uhttps://zaguan.unizar.es/record/118122/files/texto_completo.pdf$$yVersión publicada
000118122 8564_ $$s3345458$$uhttps://zaguan.unizar.es/record/118122/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000118122 909CO $$ooai:zaguan.unizar.es:118122$$particulos$$pdriver
000118122 951__ $$a2024-03-18-12:29:05
000118122 980__ $$aARTICLE