000118137 001__ 118137
000118137 005__ 20230519145519.0
000118137 0247_ $$2doi$$a10.1038/s41598-021-97382-5
000118137 0248_ $$2sideral$$a126385
000118137 037__ $$aART-2021-126385
000118137 041__ $$aeng
000118137 100__ $$aAndersen, MHG
000118137 245__ $$aOccupational exposure and markers of genetic damage, systemic inflammation and lung function: a Danish cross-sectional study among air force personnel
000118137 260__ $$c2021
000118137 5060_ $$aAccess copy available to the general public$$fUnrestricted
000118137 5203_ $$aAir force ground crew personnel are potentially exposed to fuels and lubricants, as raw materials, vapours and combustion exhaust emissions, during operation and maintenance of aircrafts. This study investigated exposure levels and biomarkers of effects for employees at a Danish air force military base. We enrolled self-reported healthy and non-smoking employees (n = 79) and grouped them by exposure based on job function, considered to be potentially exposed (aircraft engineers, crew chiefs, fuel operators and munition specialists) or as reference group with minimal occupational exposure (avionics and office workers). We measured exposure levels to polycyclic aromatic hydrocarbons (PAHs) and organophosphate esters (OPEs) by silicone bands and skin wipes (PAHs only) as well as urinary excretion of PAH metabolites (OH-PAHs). Additionally, we assessed exposure levels of ultrafine particles (UFPs) in the breathing zone for specific job functions. As biomarkers of effect, we assessed lung function, plasma levels of acute phase inflammatory markers, and genetic damage levels in peripheral blood cells. Exposure levels of total PAHs, OPEs and OH-PAHs did not differ between exposure groups or job functions, with low correlations between PAHs in different matrices. Among the measured job functions, the UFP levels were higher for the crew chiefs. The exposure level of the PAH fluorene was significantly higher for the exposed group than the reference group (15.9 +/- 23.7 ng/g per 24 h vs 5.28 +/- 7.87 ng/g per 24 h, p = 0.007), as was the OPE triphenyl phosphate (305 +/- 606 vs 19.7 +/- 33.8 ng/g per 24 h, p = 0.011). The OPE tris(1, 3-dichlor-2-propyl)phosphate had a higher mean in the exposed group (60.7 +/- 135 ng/g per 24 h) compared to the reference group (8.89 +/- 15.7 ng/g per 24 h) but did not reach significance. No evidence of effects for biomarkers of systemic inflammation, genetic damage or lung function was found. Overall, our biomonitoring study show limited evidence of occupational exposure of air force ground crew personnel to UFPs, PAHs and OPEs. Furthermore, the OH-PAHs and the assessed biomarkers of early biological effects did not differ between exposed and reference groups.
000118137 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000118137 592__ $$a1.005$$b2021
000118137 590__ $$a4.997$$b2021
000118137 593__ $$aMultidisciplinary$$c2021$$dQ1
000118137 591__ $$aMULTIDISCIPLINARY SCIENCES$$b19 / 74 = 0.257$$c2021$$dQ2$$eT1
000118137 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000118137 700__ $$aSaber, AT
000118137 700__ $$aFrederiksen, M
000118137 700__ $$aClausen, PA
000118137 700__ $$aSejbaek, CS
000118137 700__ $$aHemmingsen, CH
000118137 700__ $$aEbbehoj, NE
000118137 700__ $$0(orcid)0000-0003-2936-242X$$aCatalan, J$$uUniversidad de Zaragoza
000118137 700__ $$aAimonen, K
000118137 700__ $$aKoivisto, J
000118137 700__ $$aLoft, S
000118137 700__ $$aMoller, P
000118137 700__ $$aVogel, U
000118137 7102_ $$11001$$2420$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Genética
000118137 773__ $$g11, 1 (2021), [14 pp]$$pSci. rep. (Nat. Publ. Group)$$tScientific reports (Nature Publishing Group)$$x2045-2322
000118137 8564_ $$s1035976$$uhttps://zaguan.unizar.es/record/118137/files/texto_completo.pdf$$yVersión publicada
000118137 8564_ $$s2266719$$uhttps://zaguan.unizar.es/record/118137/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000118137 909CO $$ooai:zaguan.unizar.es:118137$$particulos$$pdriver
000118137 951__ $$a2023-05-18-15:21:44
000118137 980__ $$aARTICLE