118140 20231219145819.0 doi 10.3390/ani11113121 sideral 126830 ART-2021-126830 eng García-Belenguer S. Universidad de Zaragoza (orcid)0000-0001-5084-6555 Gut microbiota in canine idiopathic epilepsy: Effects of disease and treatment 2021 Access copy available to the general public Unrestricted Epilepsy is one of the most common neurological disorders in humans and dogs. The structure and composition of gut microbiome associated to this disorder has not yet been analyzed in depth but there is evidence that suggests a possible influence of gut bacteria in controlling seizures. The aim of this study was to investigate the changes in gut microbiota associated to canine idiopathic epilepsy (IE) and the possible influence of antiepileptic drugs (AEDs) on the modulation of this microbiota. Faecal microbiota composition was analyzed using sequencing of bacterial 16S rRNA gene in a group of healthy controls (n = 12) and a group of epileptic dogs both before (n = 10) and after a 30-day single treatment with phenobarbital or imepitoin (n = 9). Epileptic dogs showed significantly reduced abundance of GABA (Pseudomonadales, Pseudomonadaceae, Pseudomonas and Pseudomona_graminis) and SCFAs-producing bacteria (Peptococcaceae, Ruminococcaceae and Anaerotruncus) as well as bacteria associated with reduced risk for brain disease (Prevotellaceae) than control dogs. The administration of AEDs during 30 days did not modify the gut microbiota composition. These results are expected to contribute to the understanding of canine idiopathic epilepsy and open up the possibility of studying new therapeutic approaches for this disorder, including probiotic intervention to restore gut microbiota in epileptic individuals. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 3.231 2021 VETERINARY SCIENCES 16 / 145 = 0.11 2021 Q1 T1 AGRICULTURE, DAIRY & ANIMAL SCIENCE 13 / 62 = 0.21 2021 Q1 T1 0.61 2021 Veterinary (miscellaneous) 2021 Q1 Animal Science and Zoology 2021 Q1 2.7 2021 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Grasa L. Universidad de Zaragoza (orcid)0000-0002-5306-9365 Valero O. Palacio J. Universidad de Zaragoza (orcid)0000-0002-1581-3085 Luño I. Universidad de Zaragoza (orcid)0000-0001-7610-6344 Rosado B. Universidad de Zaragoza (orcid)0000-0003-1728-900X 1012 410 Universidad de Zaragoza Dpto. Farmac.Fisiol.y Med.L.F. Área Fisiología 1009 617 Universidad de Zaragoza Dpto. Patología Animal Área Medicina y Cirugía Animal 11, 11 (2021), 3121 [16 pp] Animals (Basel) Animals 2076-2615 914756 http://zaguan.unizar.es/record/118140/files/texto_completo.pdf Versión publicada 2583945 http://zaguan.unizar.es/record/118140/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:118140 articulos driver 2023-12-19-14:45:44 ARTICLE