118204 20240319081020.0 doi 10.3390/biomedicines10051094 sideral 129600 ART-2022-129600 eng Lapuente, J. P. Evaluation in a Cytokine Storm Model in Vivo of the Safety and Efficacy of Intravenous Administration of PRS CK STORM (Standardized Conditioned Medium Obtained by Coculture of Monocytes and Mesenchymal Stromal Cells) 2022 Access copy available to the general public Unrestricted Our research group has been developing a series of biological drugs produced by cocul-ture techniques with M2-polarized macrophages with different primary tissue cells and/or mesen-chymal stromal cells (MSC), generally from fat, to produce anti-inflammatory and anti-fibrotic ef-fects, avoiding the overexpression of pro-inflammatory cytokines by the innate immune system at a given time. One of these products is the drug PRS CK STORM, a medium conditioned by allogenic M2-polarized macrophages, from coculture, with those macrophages M2 with MSC from fat, whose composition, in vitro safety, and efficacy we studied. In the present work, we publish the results obtained in terms of safety (pharmacodynamics and pharmacokinetics) and efficacy of the intravenous application of this biological drug in a murine model of cytokine storm associated with severe infectious processes, including those associated with COVID-19. The results demonstrate the safety and high efficacy of PRS CK STORM as an intravenous drug to prevent and treat the cytokine storm associated with infectious processes, including COVID-19. info:eu-repo/grantAgreement/ES/DGA/B31-20R info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 4.7 2022 PHARMACOLOGY & PHARMACY 68 / 278 = 0.245 2022 Q1 T1 BIOCHEMISTRY & MOLECULAR BIOLOGY 92 / 285 = 0.323 2022 Q2 T1 MEDICINE, RESEARCH & EXPERIMENTAL 54 / 136 = 0.397 2022 Q2 T2 0.897 2022 Medicine (miscellaneous) 2022 Q1 Biochemistry, Genetics and Molecular Biology (miscellaneous) 2022 Q2 3.7 2022 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Gómez, G. Marco-Brualla, J. Fernández, P. Desportes, P. Sanz, J. García-Gil, M. Bermejo, F. Martín, J. V. S. Algaba, A. De Gregorio, J. C. Lapuente, D. De Gregorio, A. Lapuente, B. Gómez, S. de las Viñas Andrés, M. Anel Bernal, A. Universidad de Zaragoza (orcid)0000-0002-5175-8394 1002 060 Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Área Bioquímica y Biolog.Mole. 10, 5 (2022), 1094 [27 pp] Biomedicines 2227-9059 4301701 http://zaguan.unizar.es/record/118204/files/texto_completo.pdf Versión publicada 2911246 http://zaguan.unizar.es/record/118204/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:118204 articulos driver 2024-03-18-16:08:39 ARTICLE