118218 20260112133149.0 doi 10.1186/s12931-022-02092-9 sideral 129616 ART-2022-129616 eng Marín-Oto, M. Universidad de Zaragoza (orcid)0000-0003-0777-3850 Soluble RAGE in COPD, with or without coexisting obstructive sleep apnoea 2022 Access copy available to the general public Unrestricted Background: Hypoxia can reduce the levels of soluble receptor for advanced glycation end-products (sRAGE), a new anti-inflammatory biomarker of COPD. We assessed sRAGE in patients with hypoxia-related diseases such as COPD, OSA and OSA-COPD overlap. Methods: Plasma levels of sRAGE were measured in 317 subjects at baseline (57 heathy nonsmokers HNS], 84 healthy smokers HS], 79 OSA, 62 COPD and 35 OSA-COPD overlap patients) and in 294 subjects after one year of follow-up (50 HNS, 74 HS, 77 OSA, 60 COPD and 33 overlap). Results: After adjusting for age, sex, smoking status and body mass index, sRAGE levels showed a reduction in OSA (- 12.5%, p = 0.005), COPD (- 14.8%, p < 0.001) and OSA-COPD overlap (- 12.3%, p = 0.02) compared with HNS. There were no differences when comparing sRAGE plasma levels between overlap patients and those with OSA or COPD alone. At follow-up, sRAGE levels did not change significantly in healthy subjects, COPD and OSA or OSA-COPD overlap nontreated with continuous positive airway pressure (CPAP). Moreover, in patients with OSA and OSA-COPD overlap who were treated with CPAP, sRAGE increased significantly. Conclusions: The levels of sRAGE are reduced in COPD and OSA. Treatment with CPAP appears to improve sRAGE levels in patients with OSA who also had COPD. info:eu-repo/grantAgreement/ES/ISCIII-FEDER-FIS/PI18-01524 info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI12-02175 info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI15-01940 info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es 5.8 2022 RESPIRATORY SYSTEM 15 / 66 = 0.227 2022 Q1 T1 1.753 2022 Pulmonary and Respiratory Medicine 2022 Q1 9.5 2022 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Sanz-Rubio, D. (orcid)0000-0002-5228-248X Santamaría-Martos, F. Benitez, I. Simon, A. L. Forner, M. Cubero, P. Gil, A. Sánchez de la Torre, M. Barbe, F. Marín, J. M. Universidad de Zaragoza (orcid)0000-0001-9096-2294 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 23 (2022), 163 [9 pp.] Respir. res. Respiratory Research 1465-9921 1114956 http://zaguan.unizar.es/record/118218/files/texto_completo.pdf Versión publicada 2473907 http://zaguan.unizar.es/record/118218/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:118218 articulos driver 2026-01-12-12:37:10 ARTICLE