118221 20240319081023.0 doi 10.3390/antiox11061086 sideral 129662 ART-2022-129662 eng Pinilla, Isabel Universidad de Zaragoza (orcid)0000-0003-0349-9997 Inherited retinal dystrophies: role of oxidative stress and inflammation in their physiopathology and therapeutic implications 2022 Access copy available to the general public Unrestricted Inherited retinal dystrophies (IRDs) are a large group of genetically and clinically heteroge-neous diseases characterized by the progressive degeneration of the retina, ultimately leading to loss of visual function. Oxidative stress and inflammation play fundamental roles in the physiopathology of these diseases. Photoreceptor cell death induces an inflammatory state in the retina. The activation of several molecular pathways triggers different cellular responses to injury, including the activation of microglia to eliminate debris and recruit inflammatory cells from circulation. Therapeutical options for IRDs are currently limited, although a small number of patients have been successfully treated by gene therapy. Many other therapeutic strategies are being pursued to mitigate the deleterious effects of IRDs associated with oxidative metabolism and/or inflammation, including inhibiting reactive oxygen species’ accumulation and inflammatory responses, and blocking autophagy. Several compounds are being tested in clinical trials, generating great expectations for their implementation. The present review discusses the main death mechanisms that occur in IRDs and the latest therapies that are under investigation. © 2022 by the authors. Licensee MDPI, Basel, Switzerland. info:eu-repo/grantAgreement/ES/DGA/B08-17R info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI20-00740 info:eu-repo/grantAgreement/ES/ISCIII/RETICS-FEDER-RD16-0008-0016 info:eu-repo/grantAgreement/ES/MEC/FPU16-04114 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 7.0 2022 BIOCHEMISTRY & MOLECULAR BIOLOGY 46 / 285 = 0.161 2022 Q1 T1 FOOD SCIENCE & TECHNOLOGY 13 / 142 = 0.092 2022 Q1 T1 CHEMISTRY, MEDICINAL 6 / 60 = 0.1 2022 Q1 T1 1.084 2022 Biochemistry 2022 Q1 Clinical Biochemistry 2022 Q1 Food Science 2022 Q1 Physiology 2022 Q1 Molecular Biology 2022 Q2 Cell Biology 2022 Q2 8.8 2022 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Maneu, Victoria Campello, Laura Fernández Sánchez, Laura Martínez Gil, Natalia Kutsyr, Oksana Sánchez Sáez, Xabier Sánchez Castillo, Carla Lax, Pedro Cuenca, Nicolás 1013 646 Universidad de Zaragoza Dpto. Cirugía Área Oftalmología 11, 6 (2022), 1086 [55 pp.] Antioxidants Antioxidants 2076-3921 814468 http://zaguan.unizar.es/record/118221/files/texto_completo.pdf Versión publicada 2649880 http://zaguan.unizar.es/record/118221/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:118221 articulos driver 2024-03-18-16:27:04 ARTICLE