000118222 001__ 118222
000118222 005__ 20240319081023.0
000118222 0247_ $$2doi$$a10.3390/ijms23137049
000118222 0248_ $$2sideral$$a129665
000118222 037__ $$aART-2022-129665
000118222 041__ $$aeng
000118222 100__ $$aPla López, A.
000118222 245__ $$aSynthesis and biological evaluation of small molecules as potential anticancer multitarget agents
000118222 260__ $$c2022
000118222 5060_ $$aAccess copy available to the general public$$fUnrestricted
000118222 5203_ $$aTwenty-six triazole-based derivatives were designed for targeting both PD-L1 (programmed death receptor ligand 1) and VEGFR-2 (vascular endothelial growth factor receptor 2). These compounds were synthetized and biologically evaluated as multitarget inhibitors of VEGFR-2, PD-L1 and c-Myc proteins. The antiproliferative activity of these molecules on several tumor cell lines (HT-29, A-549, and MCF-7) and on the non-tumor cell line HEK-293 was determined. The effects on the abovementioned biological targets were evaluated for some selected compounds. Compound 23, bearing a p-chlorophenyl group, showed better results than sorafenib in regard to the downregulation of VEGFR-2 and a similar effect to BMS-8 on both PD-L1 and c-Myc proteins. The antiangiogenic and antivascular activities of chloro derivatives were also established by endothelial microtube formation assay on Matrigel.
000118222 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000118222 590__ $$a5.6$$b2022
000118222 592__ $$a1.154$$b2022
000118222 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b66 / 285 = 0.232$$c2022$$dQ1$$eT1
000118222 593__ $$aMedicine (miscellaneous)$$c2022$$dQ1
000118222 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b52 / 178 = 0.292$$c2022$$dQ2$$eT1
000118222 593__ $$aPhysical and Theoretical Chemistry$$c2022$$dQ1
000118222 593__ $$aComputer Science Applications$$c2022$$dQ1
000118222 593__ $$aInorganic Chemistry$$c2022$$dQ1
000118222 593__ $$aSpectroscopy$$c2022$$dQ1
000118222 593__ $$aOrganic Chemistry$$c2022$$dQ1
000118222 593__ $$aMolecular Biology$$c2022$$dQ2
000118222 593__ $$aCatalysis$$c2022$$dQ2
000118222 594__ $$a7.8$$b2022
000118222 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000118222 700__ $$aCastillo, R.
000118222 700__ $$aCejudo Marín, R.
000118222 700__ $$aGarcía Pedrero, O.
000118222 700__ $$0(orcid)0000-0002-8066-7117$$aBakir Laso, M.$$uUniversidad de Zaragoza
000118222 700__ $$aFalomir, E.
000118222 700__ $$aCarda, M.
000118222 7102_ $$12009$$2750$$aUniversidad de Zaragoza$$bDpto. Química Analítica$$cÁrea Química Analítica
000118222 773__ $$g23, 13 (2022), 7049 [19 pp.]$$pInt. j. mol. sci.$$tInternational Journal of Molecular Sciences$$x1661-6596
000118222 8564_ $$s3372035$$uhttps://zaguan.unizar.es/record/118222/files/texto_completo.pdf$$yVersión publicada
000118222 8564_ $$s2790343$$uhttps://zaguan.unizar.es/record/118222/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000118222 909CO $$ooai:zaguan.unizar.es:118222$$particulos$$pdriver
000118222 951__ $$a2024-03-18-16:27:42
000118222 980__ $$aARTICLE