000118262 001__ 118262
000118262 005__ 20230519145543.0
000118262 0247_ $$2doi$$a10.1002/chem.202103048
000118262 0248_ $$2sideral$$a126928
000118262 037__ $$aART-2021-126928
000118262 041__ $$aeng
000118262 100__ $$aKordestani N.
000118262 245__ $$aThe significant influence of a second metal on the antiproliferative properties of the complex [Ru(¿6-C10H14)(Cl2)(dmoPTA)]
000118262 260__ $$c2021
000118262 5060_ $$aAccess copy available to the general public$$fUnrestricted
000118262 5203_ $$aComplexes [Ru(¿6-C10H14)(Cl2)(HdmoPTA)](OSO2CF3) (1), [Ru(¿6-C10H14)(Cl2)(dmoPTA)] (2) and [Ru(¿6-C10H14)(Cl2)-µ-dmoPTA-1¿P:2¿2N, N’-MCl2] (M=Zn (3), Co (4), Ni (5), dmoPTA=3, 7-dimethyl-1, 3, 7-triaza-5-phosphabicyclo[3.3.1]nonane) have been synthesized and characterized by elemental analysis and spectroscopic techniques. The crystal structures of 1, 3 and 5 were obtained by single-crystal X-ray diffraction. The antiproliferative activity of the complexes was evaluated against colon cancer cell line Caco-2/TC7 by using the MTT protocol. The monometallic ruthenium complexes 1 and 2 were found to be inactive, but the bimetallic complexes 3, 4 and 5 display an increased activity (IC50 3: 9.07±0.27, 4: 5.40±0.19, 5: 7.15±0.30 µM) compared to cisplatin (IC50=45.6±8.08 µM). Importantly, no reduction in normal cell viability was observed in the presence of the complexes. Experiments targeted to obtain information on the possible action mechanism of the complexes, such as cell cycle, ROS and gene expression studies, were performed. The results showed that the complexes display different properties and action mechanism depending on the nature of metal, M, bonded to the CH3NdmoPTA atoms. © 2021 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH
000118262 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/
000118262 590__ $$a5.02$$b2021
000118262 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b64 / 180 = 0.356$$c2021$$dQ2$$eT2
000118262 592__ $$a1.343$$b2021
000118262 593__ $$aChemistry (miscellaneous)$$c2021$$dQ1
000118262 593__ $$aCatalysis$$c2021$$dQ1
000118262 594__ $$a9.1$$b2021
000118262 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000118262 700__ $$0(orcid)0000-0002-6674-7364$$aAbas, Elisa$$uUniversidad de Zaragoza
000118262 700__ $$0(orcid)0000-0002-5306-9365$$aGrasa, Laura$$uUniversidad de Zaragoza
000118262 700__ $$aAlguacil, Andrés
000118262 700__ $$aScalambra, Franco
000118262 700__ $$aRomerosa, Antonio
000118262 7102_ $$12009$$2750$$aUniversidad de Zaragoza$$bDpto. Química Analítica$$cÁrea Química Analítica
000118262 7102_ $$11012$$2410$$aUniversidad de Zaragoza$$bDpto. Farmac.Fisiol.y Med.L.F.$$cÁrea Fisiología
000118262 773__ $$g28, 3 (2021), 202103048 [12p]$$pChemistry (Weinh.)$$tChemistry - A European Journal$$x0947-6539
000118262 8564_ $$s2307255$$uhttps://zaguan.unizar.es/record/118262/files/texto_completo.pdf$$yVersión publicada
000118262 8564_ $$s1504318$$uhttps://zaguan.unizar.es/record/118262/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000118262 909CO $$ooai:zaguan.unizar.es:118262$$particulos$$pdriver
000118262 951__ $$a2023-05-18-15:41:39
000118262 980__ $$aARTICLE