doi:10.1016/j.chroma.2022.463186engMarsol-Vall, A.Ainsa, S.López, R.Ferreira, V.Development and validation of a method for the analysis of halophenols and haloanisoles in cork bark macerates by stir bar sorptive extraction heart-cutting two-dimensional gas chromatography negative chemical ionization mass spectrometryART-2022-129617A method has been developed for the quantitative determination in cork bark macerates of 7halophenols and 5haloanisoles with demonstrated or suspected contribution to the cork taint off-flavour. Macerates were extracted with stirbar (20 mm polydimethylsiloxane-coated) sorptive extraction under optimized conditions (pH 3.5, 20% NaCl and 60 min). The bars were analysed byautomated thermal desorption, heart-cutting two-dimensional gas chromatography and negative chemical ionization-mass spectrometry. Matrix effects were compensated for by a “matrix matched” calibration curve. Limits of detection were in the range 0.03-0.24 ng L-1, below the corresponding odor thresholds. Linearity (0.983 = R2 = 0.998), intra- and inter-day precision (5.4-14.3%) and accuracy (89–126%) were satisfactory. The analysis of 48 natural cork bark samples affected/not-affected bya cryptogamic disease (yellow spot) revealed compositional differences in 2, 4, 6-trichloroanisole (2, 4, 6-TCA), 2, 4, 6-trichlorophenol (2, 4, 6-TCP) and also in 2, 6-dibromophenol, 2, 3, 4- and 2, 4, 5-TCP, 2, 3, 4-TCA and 2, 3, 4, 6-tetrachlorophenol (2, 3, 4, 6-TeCP). In addition, the contents of 2, 4, 6-TCP and 2, 4, 6-TCA, and 2, 3, 4, 6-TeCP and some TCPs presented strong linear correlations.2022http://zaguan.unizar.es/record/11828310.1016/j.chroma.2022.463186http://zaguan.unizar.es/record/118283oai:zaguan.unizar.es:118283info:eu-repo/grantAgreement/ES/MICIU/FJCI-2018-035486-IJournal of Chromatography A 1673 (2022), 463186 [8 pp.]byhttp://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccess