000118622 001__ 118622
000118622 005__ 20230519145529.0
000118622 0247_ $$2doi$$a10.1038/s41390-021-01471-0
000118622 0248_ $$2sideral$$a126678
000118622 037__ $$aART-2021-126678
000118622 041__ $$aeng
000118622 100__ $$0(orcid)0000-0003-2005-8229$$aGonzález-Gil E.M.$$uUniversidad de Zaragoza
000118622 245__ $$aImproving cardiorespiratory fitness protects against inflammation in children: the IDEFICS study
000118622 260__ $$c2021
000118622 5060_ $$aAccess copy available to the general public$$fUnrestricted
000118622 5203_ $$aBackground: Muscular and cardiorespiratory fitness (MF and CRF) have been related to inflammation. Thus, the aim of this study was to assess the relationship between fitness and high-sensitivity C-reactive protein (hs-CRP) in European children both in the cross-sectional and longitudinal analysis. Methods: Three hundred and fifty-seven children (46.2% males) aged 2–9 years with hs-CRP measured, data from MF and CRF, diet quality, objectively measured physical activity (PA) and screen time at baseline and follow-up after 2 years were included. Body mass index z-score (zBMI), waist circumference (WC) and fat mass index (FMI) were assessed. MF and CRF were also dichotomized as follows: low-medium quartiles (Q1–Q3) and highest quartile (Q4). Results: At follow-up, children with the highest CRF (Q4) showed a lower probability of having high hs-CRP. In the longitudinal analysis, children who improved their CRF over time showed a significantly lower probability (p < 0.05) of being in the highest hs-CRP category at follow-up, independently of the body composition index considered: odds ratio (OR) = 0.22 for zBMI, OR = 0.17 for WC, and OR = 0.21 for FMI. Conclusions: Improving CRF during childhood reduces the odds of an inflammatory profile, independently of body composition and lifestyle behaviours. These highlight the importance of enhancing fitness, especially CRF, to avoid an inflammatory state in children. Impact: Improvements in the cardiorespiratory profile during childhood could reverse an unfavourable inflammatory status.There is a longitudinal and inverse association between CRF and inflammation in children.This is the first longitudinal study assessing the relationship between fitness and inflammation during childhood that takes also into account the lifestyle behaviours.Results from the present study suggest a protective role of fitness already in childhood.Efforts to improve fitness in children should be aimed at as inflammation could trigger future cardiovascular disease. © 2021, The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc.
000118622 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000118622 590__ $$a3.953$$b2021
000118622 591__ $$aPEDIATRICS$$b26 / 130 = 0.2$$c2021$$dQ1$$eT1
000118622 592__ $$a0.991$$b2021
000118622 593__ $$aPediatrics, Perinatology and Child Health$$c2021$$dQ1
000118622 594__ $$a5.7$$b2021
000118622 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000118622 700__ $$aSantaliestra-Pasías A.M.
000118622 700__ $$aBuck C.
000118622 700__ $$aGracia-Marco L.
000118622 700__ $$aLauria F.
000118622 700__ $$aPala V.
000118622 700__ $$aMolnar D.
000118622 700__ $$aVeidebaum T.
000118622 700__ $$aIacoviello L.
000118622 700__ $$aTornaritis M.
000118622 700__ $$aEiben G.
000118622 700__ $$aLissner L.
000118622 700__ $$aSchwarz H.
000118622 700__ $$aAhrens W.
000118622 700__ $$aDe Henauw S.
000118622 700__ $$aFraterman A.
000118622 700__ $$0(orcid)0000-0003-0454-653X$$aMoreno L.A.$$uUniversidad de Zaragoza
000118622 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000118622 773__ $$g(2021), [9 pp]$$pPediatr. res.$$tPediatric research$$x0031-3998
000118622 8564_ $$s197996$$uhttps://zaguan.unizar.es/record/118622/files/texto_completo.pdf$$yPostprint
000118622 8564_ $$s1255887$$uhttps://zaguan.unizar.es/record/118622/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000118622 909CO $$ooai:zaguan.unizar.es:118622$$particulos$$pdriver
000118622 951__ $$a2023-05-18-15:29:15
000118622 980__ $$aARTICLE