000118630 001__ 118630
000118630 005__ 20230519145536.0
000118630 0247_ $$2doi$$a10.3390/biom11070977
000118630 0248_ $$2sideral$$a126877
000118630 037__ $$aART-2021-126877
000118630 041__ $$aeng
000118630 100__ $$aVelderrain Rodríguez G.R.
000118630 245__ $$aPhenolic-rich extracts from avocado fruit residues as functional food ingredients with antioxidant and antiproliferative properties
000118630 260__ $$c2021
000118630 5060_ $$aAccess copy available to the general public$$fUnrestricted
000118630 5203_ $$aIn this study, the total phenolic compounds content and profile, the nutritional value, the antioxidant and antiproliferative activities of avocado peel, seed coat, and seed extracts were characterized. Additionally, an in-silico analysis was performed to identify the phenolic compounds with the highest intestinal absorption and Caco-2 permeability. The avocado peel extract possessed the highest content of phenolic compounds (309.95 ± 25.33 mMol GA/100 g of extract) and the lowest effective concentration (EC50) against DPPH and ABTS radicals (72.64 ± 10.70 and 181.68 ± 18.47, respectively). On the other hand, the peel and seed coat extracts had the lowest energy densities (226.06 ± 0.06 kcal/100g and 219.62 ± 0.49 kcal/100g, respectively). Regarding the antiproliferative activity, the avocado peel extract (180 ± 40 µg/mL) showed the lowest inhibitory concentration (IC50), followed by the seed (200 ± 21 µg/mL) and seed coat (340 ± 32 µg/mL) extracts. The IC50 of the extracts induced apoptosis in Caco-2 cells at the early and late stages. According to the in-silico analysis, these results could be related to the higher Caco-2 permeability to hy-droxysalidroside, salidroside, sakuranetin, and luteolin. Therefore, this study provides new insights regarding the potential use of these extracts as functional ingredients with antioxidant and antiproliferative properties and as medicinal agents in diseases related to oxidative stress such as cancer. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
000118630 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000118630 590__ $$a6.064$$b2021
000118630 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b75 / 297 = 0.253$$c2021$$dQ2$$eT1
000118630 592__ $$a1.019$$b2021
000118630 593__ $$aMolecular Biology$$c2021$$dQ2
000118630 593__ $$aBiochemistry$$c2021$$dQ2
000118630 594__ $$a5.7$$b2021
000118630 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000118630 700__ $$aQuero J.
000118630 700__ $$0(orcid)0000-0002-8251-8457$$aOsada García, J.$$uUniversidad de Zaragoza
000118630 700__ $$aMartín Belloso O.
000118630 700__ $$0(orcid)0000-0002-3595-7668$$aRodríguez Yoldi M.J.$$uUniversidad de Zaragoza
000118630 7102_ $$11012$$2410$$aUniversidad de Zaragoza$$bDpto. Farmac.Fisiol.y Med.L.F.$$cÁrea Fisiología
000118630 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000118630 773__ $$g11, 7 (2021), 977 [22 pp]$$tBiomolecules$$x2218-273X
000118630 8564_ $$s1884201$$uhttps://zaguan.unizar.es/record/118630/files/texto_completo.pdf$$yVersión publicada
000118630 8564_ $$s2795519$$uhttps://zaguan.unizar.es/record/118630/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000118630 909CO $$ooai:zaguan.unizar.es:118630$$particulos$$pdriver
000118630 951__ $$a2023-05-18-15:35:47
000118630 980__ $$aARTICLE