000118649 001__ 118649
000118649 005__ 20240319081018.0
000118649 0247_ $$2doi$$a10.7554/eLife.72871
000118649 0248_ $$2sideral$$a129561
000118649 037__ $$aART-2022-129561
000118649 041__ $$aeng
000118649 100__ $$aBräcklein, M.
000118649 245__ $$aThe control and training of single motor units in isometric tasks are constrained by a common input signal
000118649 260__ $$c2022
000118649 5060_ $$aAccess copy available to the general public$$fUnrestricted
000118649 5203_ $$aRecent developments in neural interfaces enable the real-time and non-invasive tracking of motor neuron spiking activity. Such novel interfaces could provide a promising basis for human motor augmentation by extracting potentially high-dimensional control signals directly from the human nervous system. However, it is unclear how flexibly humans can control the activity of individual motor neurons to effectively increase the number of degrees of freedom available to coordinate multiple effectors simultaneously. Here, we provided human subjects (N = 7) with real-time feedback on the discharge patterns of pairs of motor units (MUs) innervating a single muscle (tibialis anterior) and encouraged them to independently control the MUs by tracking targets in a 2D space. Subjects learned control strategies to achieve the target-tracking task for various combinations of MUs. These strategies rarely corresponded to a volitional control of independent input signals to individual MUs during the onset of neural activity. Conversely, MU activation was consistent with a common input to the MU pair, while individual activation of the MUs in the pair was predominantly achieved by alterations in de-recruitment order that could be explained by history-dependent changes in motor neuron excitability. These results suggest that flexible MU recruitment based on independent synaptic inputs to single MUs is unlikely, although de-recruitment might reflect varying inputs or modulations in the neuron’s intrinsic excitability.
000118649 536__ $$9info:eu-repo/grantAgreement/EC/H2020/843408/EU/TRIMANUAL coordination assistance for hemiplegic stroke individuals/TRIMANUAL$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 843408-TRIMANUAL$$9info:eu-repo/grantAgreement/EC/H2020/899626/EU/NIMA: Non-invasive Interface for Movement Augmentation/NIMA$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 899626-NIMA
000118649 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000118649 590__ $$a7.7$$b2022
000118649 592__ $$a4.251$$b2022
000118649 591__ $$aBIOLOGY$$b7 / 92 = 0.076$$c2022$$dQ1$$eT1
000118649 593__ $$aBiochemistry, Genetics and Molecular Biology (miscellaneous)$$c2022$$dQ1
000118649 593__ $$aNeuroscience (miscellaneous)$$c2022$$dQ1
000118649 593__ $$aMedicine (miscellaneous)$$c2022$$dQ1
000118649 593__ $$aImmunology and Microbiology (miscellaneous)$$c2022$$dQ1
000118649 594__ $$a12.3$$b2022
000118649 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000118649 700__ $$aBarsakcioglu, D.Y.
000118649 700__ $$0(orcid)0000-0001-8439-151X$$aIbáñez, J.
000118649 700__ $$aEden, J.
000118649 700__ $$aBurdet, E.
000118649 700__ $$aMehring, C.
000118649 700__ $$aFarina, D.
000118649 773__ $$g11 (2022), e72871 [23 pp.]$$peLife (Cambridge)$$teLife$$x2050-084X
000118649 8564_ $$s5749925$$uhttps://zaguan.unizar.es/record/118649/files/texto_completo.pdf$$yVersión publicada
000118649 8564_ $$s2374866$$uhttps://zaguan.unizar.es/record/118649/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000118649 909CO $$ooai:zaguan.unizar.es:118649$$particulos$$pdriver
000118649 951__ $$a2024-03-18-15:56:07
000118649 980__ $$aARTICLE