118731 20240319081024.0 doi 10.3390/biomedicines10061437 sideral 129671 ART-2022-129671 eng Quero, Javier Universidad de Zaragoza (orcid)0009-0001-5345-6947 Sulfonamide-derived Dithiocarbamate Gold(i) complexes induce the apoptosis of colon cancer cells by the activation of Caspase 3 and redox imbalance 2022 Access copy available to the general public Unrestricted Two new families of dithiocarbamate gold(I) complexes derived from benzenesulfonamide with phosphine or carbene as ancillary ligands have been synthesized and characterized. In the screening of their in vitro activity on human colon carcinoma cells (Caco-2), we found that the more lipophilic complexes—those with the phosphine PPh3—exhibited the highest anticancer activity whilst also displaying significant cancer cell selectivity. Au(S2CNHSO2C6H5)(PPh3)] (1) and Au(S2CNHSO2-p-Me-C6H4)(IMePropargyl)] (8) produce cell death, probably by intrinsic apoptosis (mitochondrial membrane potential modification) and caspase 3 activation, causing cell cycle arrest in the G1 phase with p53 activation. Besides this, both complexes might act as multi-target anticancer drugs, as they inhibit the activity of the enzymes thioredoxin reductase (TrxR) and carbonic anhydrase (CA IX) with the alteration of the redox balance, and show a pro-oxidant effect. info:eu-repo/grantAgreement/ES/CIBERObn/CB06-03-1012 info:eu-repo/grantAgreement/ES/DGA/B16-20R info:eu-repo/grantAgreement/ES/DGA/E06-20R info:eu-repo/grantAgreement/ES/MCIU/RED2018-102471-T info:eu-repo/grantAgreement/ES/MICINN AEI/PID2019-104915RB-I00 info:eu-repo/grantAgreement/ES/MICINN/PID2019-104379RB-C21-AEI-10.13039-501100011033 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 4.7 2022 PHARMACOLOGY & PHARMACY 68 / 278 = 0.245 2022 Q1 T1 BIOCHEMISTRY & MOLECULAR BIOLOGY 92 / 285 = 0.323 2022 Q2 T1 MEDICINE, RESEARCH & EXPERIMENTAL 54 / 136 = 0.397 2022 Q2 T2 0.897 2022 Medicine (miscellaneous) 2022 Q1 Biochemistry, Genetics and Molecular Biology (miscellaneous) 2022 Q2 3.7 2022 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Royo, José Carlos Fodor, Beatrice Gimeno, María Concepción (orcid)0000-0003-0553-0695 Osada, Jesús Universidad de Zaragoza (orcid)0000-0002-8251-8457 Rodríguez Yoldi, María Jesús Universidad de Zaragoza (orcid)0000-0002-3595-7668 Cerrada, Elena Universidad de Zaragoza (orcid)0000-0003-2457-3674 2010 760 Universidad de Zaragoza Dpto. Química Inorgánica Área Química Inorgánica 1012 410 Universidad de Zaragoza Dpto. Farmac.Fisiol.y Med.L.F. Área Fisiología 1002 060 Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Área Bioquímica y Biolog.Mole. 10, 6 (2022), 1437 [19 pp.] Biomedicines 2227-9059 1841196 http://zaguan.unizar.es/record/118731/files/texto_completo.pdf Versión publicada 2811390 http://zaguan.unizar.es/record/118731/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:118731 articulos driver 2024-03-18-16:29:41 ARTICLE