000118792 001__ 118792
000118792 005__ 20240319080950.0
000118792 0247_ $$2doi$$a10.1002/jemt.23976
000118792 0248_ $$2sideral$$a126938
000118792 037__ $$aART-2022-126938
000118792 041__ $$aeng
000118792 100__ $$0(orcid)0000-0001-7453-2470$$aCastiella, T.
000118792 245__ $$aStromal cells of giant cell tumor of bone show primary cilia in giant cell tumor of bone
000118792 260__ $$c2022
000118792 5060_ $$aAccess copy available to the general public$$fUnrestricted
000118792 5203_ $$aGiant cell tumor of bone (GCTB) is a locally aggressive primary bone neoplasm com-posed by tumoral stromal cells (SCs) and a reactive component that consists ofmonocytic/histiocytic cells that give rise by fusion to osteoclast-like multinucleatedcells. Recently, specific Histone 3.3 mutations have been demonstrated in SCs ofGCTB. Many of the pathways related to bone proliferation and regulation depend onthe primary cilium, a microtubule-based organelle that protrudes outside the cell andacts as a sensorial antenna. In the present work, we aimed to study the presence androle of primary cilia in GCTB. Ultrastructural, immunohistochemical, and immunofluo-rescence studies were performed in order to demonstrate, for the first time, that theprimary cilium is located in spindle-shaped SCs of GCTB. Moreover, we showedHedgehog (Hh) signaling pathway activation in these cells. Hence, primary cilia mayplay a relevant role in GCTB tumorogenesis through Hh signaling activation in SCs.
000118792 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000118792 590__ $$a2.5$$b2022
000118792 591__ $$aANATOMY & MORPHOLOGY$$b5 / 20 = 0.25$$c2022$$dQ1$$eT1
000118792 591__ $$aMICROSCOPY$$b2 / 8 = 0.25$$c2022$$dQ1$$eT1
000118792 591__ $$aBIOLOGY$$b47 / 92 = 0.511$$c2022$$dQ3$$eT2
000118792 594__ $$a5.2$$b2022
000118792 592__ $$a0.552$$b2022
000118792 593__ $$aMedical Laboratory Technology$$c2022$$dQ1
000118792 593__ $$aInstrumentation$$c2022$$dQ2
000118792 593__ $$aAnatomy$$c2022$$dQ2
000118792 593__ $$aHistology$$c2022$$dQ2
000118792 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000118792 700__ $$aIruzubieta, P.
000118792 700__ $$0(orcid)0000-0002-7453-1766$$aMonleón, E.$$uUniversidad de Zaragoza
000118792 700__ $$0(orcid)0000-0002-7914-4685$$aCardiel, M. J.$$uUniversidad de Zaragoza
000118792 700__ $$aGómez-Vallejo, J.$$uUniversidad de Zaragoza
000118792 700__ $$0(orcid)0000-0002-2787-9671$$aMonzón, M.$$uUniversidad de Zaragoza
000118792 700__ $$0(orcid)0000-0002-9951-1075$$aJunquera, M. C.$$uUniversidad de Zaragoza
000118792 7102_ $$11003$$2443$$aUniversidad de Zaragoza$$bDpto. Anatom.Histolog.Humanas$$cArea Histología
000118792 7102_ $$11013$$2830$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Traumatología y Ortopedia
000118792 7102_ $$11013$$2020$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Anatomía Patológica
000118792 773__ $$g85, 3 (2022), 1065-1074$$pMicrosc. res. tech.$$tMICROSCOPY RESEARCH AND TECHNIQUE$$x1059-910X
000118792 8564_ $$s5656353$$uhttps://zaguan.unizar.es/record/118792/files/texto_completo.pdf$$yPostprint
000118792 8564_ $$s946389$$uhttps://zaguan.unizar.es/record/118792/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000118792 909CO $$ooai:zaguan.unizar.es:118792$$particulos$$pdriver
000118792 951__ $$a2024-03-18-13:00:15
000118792 980__ $$aARTICLE