000118804 001__ 118804
000118804 005__ 20240319081005.0
000118804 0247_ $$2doi$$a10.1016/j.physbeh.2022.113916
000118804 0248_ $$2sideral$$a129993
000118804 037__ $$aART-2022-129993
000118804 041__ $$aeng
000118804 100__ $$aCalpe-López, C.
000118804 245__ $$aIntermittent voluntary wheel running promotes resilience to the negative consequences of repeated social defeat in mice
000118804 260__ $$c2022
000118804 5060_ $$aAccess copy available to the general public$$fUnrestricted
000118804 5203_ $$aA novel approach to reduce the incidence of substance use disorders is to promote resilience to stress using environmental resources such as physical exercise. In the present study we test the hypothesis that Voluntary Wheel Running (VWR) during adolescence blocks the negative consequences of stress induced by intermittent repeated social defeat (IRSD). Four groups of adolescent male C57BL/6 mice were employed in the experiment; two groups were exposed to VWR (1 h, 3 days/week) from postnatal day (PND) 21 until the first social defeat (PND 47), while the remaining two groups did not have access to activity wheels (controls). On PND 47, 50, 53 and 56 mice, who had performed VWR, were exposed to an episode of social defeat by a resident aggressive mouse (VWR+IRSD group) or allowed to explore an empty cage (VWR+EXPL group). The same procedure was performed with control mice that had not undergone VWR (CONTROL+IRSD and CONTROL+EXPL groups). On PND 57, all the mice performed the Elevated Plus Maze (EPM), Hole-Board, Social Interaction, Tail Suspension and Splash tests. After an interval of 3 weeks, all mice underwent a conditioned place preference (CPP) procedure with 1 mg/kg of cocaine. Exposure to VWR prevented the negative consequences of social stress in the EPM, splash test and CPP, since the VWR+IRSD group did not display anxiety- or depression-like effects or the potentiation of cocaine reward observed in the Control+IRSD group. Our results support the idea that physical exercise promotes resilience to stress and represents an excellent target in drug abuse prevention. © 2022
000118804 536__ $$9info:eu-repo/grantAgreement/ES/MICINN/PID2020-118945RB-I00$$9info:eu-repo/grantAgreement/ES/MICINN/PSI2017-83023
000118804 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000118804 590__ $$a2.9$$b2022
000118804 592__ $$a0.753$$b2022
000118804 591__ $$aPSYCHOLOGY, BIOLOGICAL$$b5 / 14 = 0.357$$c2022$$dQ2$$eT2
000118804 593__ $$aExperimental and Cognitive Psychology$$c2022$$dQ2
000118804 591__ $$aBEHAVIORAL SCIENCES$$b17 / 52 = 0.327$$c2022$$dQ2$$eT1
000118804 593__ $$aBehavioral Neuroscience$$c2022$$dQ2
000118804 594__ $$a6.3$$b2022
000118804 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000118804 700__ $$aMartínez-Caballero, M. A.
000118804 700__ $$aGarcía-Pardo, M. P.$$uUniversidad de Zaragoza
000118804 700__ $$aAguilar, M. A.
000118804 7102_ $$14009$$2735$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicolog.Evolut.Educac
000118804 773__ $$g254 (2022), 113916 [10 pp]$$pPhysiol. behav.$$tPhysiology and Behavior$$x0031-9384
000118804 8564_ $$s2099590$$uhttps://zaguan.unizar.es/record/118804/files/texto_completo.pdf$$yVersión publicada
000118804 8564_ $$s2696090$$uhttps://zaguan.unizar.es/record/118804/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000118804 909CO $$ooai:zaguan.unizar.es:118804$$particulos$$pdriver
000118804 951__ $$a2024-03-18-14:33:01
000118804 980__ $$aARTICLE