118804 20240319081005.0 doi 10.1016/j.physbeh.2022.113916 sideral 129993 ART-2022-129993 eng Calpe-López, C. Intermittent voluntary wheel running promotes resilience to the negative consequences of repeated social defeat in mice 2022 Access copy available to the general public Unrestricted A novel approach to reduce the incidence of substance use disorders is to promote resilience to stress using environmental resources such as physical exercise. In the present study we test the hypothesis that Voluntary Wheel Running (VWR) during adolescence blocks the negative consequences of stress induced by intermittent repeated social defeat (IRSD). Four groups of adolescent male C57BL/6 mice were employed in the experiment; two groups were exposed to VWR (1 h, 3 days/week) from postnatal day (PND) 21 until the first social defeat (PND 47), while the remaining two groups did not have access to activity wheels (controls). On PND 47, 50, 53 and 56 mice, who had performed VWR, were exposed to an episode of social defeat by a resident aggressive mouse (VWR+IRSD group) or allowed to explore an empty cage (VWR+EXPL group). The same procedure was performed with control mice that had not undergone VWR (CONTROL+IRSD and CONTROL+EXPL groups). On PND 57, all the mice performed the Elevated Plus Maze (EPM), Hole-Board, Social Interaction, Tail Suspension and Splash tests. After an interval of 3 weeks, all mice underwent a conditioned place preference (CPP) procedure with 1 mg/kg of cocaine. Exposure to VWR prevented the negative consequences of social stress in the EPM, splash test and CPP, since the VWR+IRSD group did not display anxiety- or depression-like effects or the potentiation of cocaine reward observed in the Control+IRSD group. Our results support the idea that physical exercise promotes resilience to stress and represents an excellent target in drug abuse prevention. © 2022 info:eu-repo/grantAgreement/ES/MICINN/PID2020-118945RB-I00 info:eu-repo/grantAgreement/ES/MICINN/PSI2017-83023 info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 2.9 2022 PSYCHOLOGY, BIOLOGICAL 5 / 14 = 0.357 2022 Q2 T2 BEHAVIORAL SCIENCES 17 / 52 = 0.327 2022 Q2 T1 0.753 2022 Experimental and Cognitive Psychology 2022 Q2 Behavioral Neuroscience 2022 Q2 6.3 2022 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Martínez-Caballero, M. A. García-Pardo, M. P. Universidad de Zaragoza Aguilar, M. A. 4009 735 Universidad de Zaragoza Dpto. Psicología y Sociología Área Psicolog.Evolut.Educac 254 (2022), 113916 [10 pp] Physiol. behav. Physiology and Behavior 0031-9384 2099590 http://zaguan.unizar.es/record/118804/files/texto_completo.pdf Versión publicada 2696090 http://zaguan.unizar.es/record/118804/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:118804 articulos driver 2024-03-18-14:33:01 ARTICLE