000118815 001__ 118815
000118815 005__ 20240319081006.0
000118815 0247_ $$2doi$$a10.1016/j.medengphy.2022.103859
000118815 0248_ $$2sideral$$a130014
000118815 037__ $$aART-2022-130014
000118815 041__ $$aeng
000118815 100__ $$aAshrafi, M.
000118815 245__ $$aA comparison between the effect of systemic and coated drug delivery in osteoporotic bone after dental implantation
000118815 260__ $$c2022
000118815 5060_ $$aAccess copy available to the general public$$fUnrestricted
000118815 5203_ $$aThe increased life expectancy has boomed the demand of dental implants in the elderly. As a consequence, considering the effect of poorer bone quality, due to aging or associated diseases such as osteoporosis, on the success of dental restoration is becoming increasingly important. Bisphosphonates are one of the most used drugs to overcome the effect of osteoporosis as they increase bone density. Bisphosphonates modify the physiological bone remodeling process by adhering to the bone surface, reducing the activity of osteoclasts. This study aims at comparing the effect on bone remodeling of two drug delivery methods of Bisphosphonates: local delivery by coating the implant surface and systemic delivery. A chemo-mechano-biological bone remodeling model validated in a previous paper was used here. The two drug delivery schemes were modeled by means of a finite element approach. In the systemic drug delivery case, the amount of drug that reaches the bone compartment was calculated using a pharmacokinetic model while in the local drug delivery system, the dose was calculated using Fickean diffusion. In particular, the effect of Zoledronate is studied here. The two drug delivery approaches are compared between them and with a control case with no drug. The results show that the use of Bisphosphonates increases the mechanical strength of bone, thus improving the implant fixation along time. Systemic drug delivery affects the entire skeleton, while local drug delivery only affects the area around the dental implant, which reduces the side effects of Bisphosphonates, such as increasing the mineral content, which may promote bone brittleness and microdamage far from the implant. These results support the conclusion that dental implants coated with Bisphosphonates can be a good solution for osteoporotic or low bone density patients without the long-term side effects of systemic drug delivery. © 2022
000118815 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000118815 590__ $$a2.2$$b2022
000118815 592__ $$a0.504$$b2022
000118815 591__ $$aENGINEERING, BIOMEDICAL$$b71 / 96 = 0.74$$c2022$$dQ3$$eT3
000118815 593__ $$aBiophysics$$c2022$$dQ3
000118815 593__ $$aBiomedical Engineering$$c2022$$dQ3
000118815 594__ $$a4.2$$b2022
000118815 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000118815 700__ $$aGholamian, F.
000118815 700__ $$0(orcid)0000-0001-8741-6452$$aDoblare, M.$$uUniversidad de Zaragoza
000118815 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000118815 773__ $$g107 (2022), 103859 [12 pp]$$pMed. eng. phys.$$tMEDICAL ENGINEERING & PHYSICS$$x1350-4533
000118815 8564_ $$s7879437$$uhttps://zaguan.unizar.es/record/118815/files/texto_completo.pdf$$yVersión publicada
000118815 8564_ $$s2540726$$uhttps://zaguan.unizar.es/record/118815/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000118815 909CO $$ooai:zaguan.unizar.es:118815$$particulos$$pdriver
000118815 951__ $$a2024-03-18-14:40:21
000118815 980__ $$aARTICLE