000118821 001__ 118821
000118821 005__ 20240319081007.0
000118821 0247_ $$2doi$$a10.1016/j.ijpharm.2022.122003
000118821 0248_ $$2sideral$$a130020
000118821 037__ $$aART-2022-130020
000118821 041__ $$aeng
000118821 100__ $$aMiranda-Calderon, L.
000118821 245__ $$aPharmacokinetic control on the release of antimicrobial drugs from pH-responsive electrospun wound dressings
000118821 260__ $$c2022
000118821 5060_ $$aAccess copy available to the general public$$fUnrestricted
000118821 5203_ $$aThe acidic pH of healthy skin changes during wound healing due to the exposure of the inner dermal and subcutaneous tissue and due to the potential colonization of pathogenic bacteria. In chronic non-healing wounds, the pH values vary in a wide pH range but the appearance of an alkaline shift is common. After a wound is incurred, neutral pH in the wound bed is characteristic of the activation of the cascade of regenerative and remodeling processes. In order to adjust drug release to the specific pH of the wound, herein, drug-loaded wound dressings having pH-responsiveness containing antiseptics and antibiotics and exerting different release kinetics in order to have a perfect match between the drug release kinetics, and the pH conditions of each wound type, were developed. We have fabricated drug-loaded electrospun nanofibers loaded with the antiseptic chlorhexidine, with the broad-spectrum antibiotic rifampicin, and with the antimicrobial of natural origin thymol, using the pH-dependent methacrylic acid copolymer Eudragit® L100-55, which dissolves at pH > 5.5; those drugs were loaded within Eudragit® S100, which dissolves at pH > 7 and, finally, within the methacrylic ester copolymer Eudragit® RS100 which is pH independent and slowly erodes and releases its contained cargo. The antibacterial action of those advanced wound dressings has been evaluated against methicillin-sensitive S. aureus Newman strain expressing the coral green fluorescent protein (cGFP), as a model of a Gram-positive bacteria, and against E. coli S17 strain as a model of a Gram-negative bacteria. It was demonstrated that those combinational products integrate in one device the required characteristics for a wound dressing with the therapeutic action of a contained active principle and can be selected depending on the wound acidic or alkaline status for its appropriated management. © 2022 The Author(s)
000118821 536__ $$9info:eu-repo/grantAgreement/ES/MICINN/PID2020-113987RB-I00
000118821 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000118821 590__ $$a5.8$$b2022
000118821 592__ $$a0.906$$b2022
000118821 591__ $$aPHARMACOLOGY & PHARMACY$$b39 / 278 = 0.14$$c2022$$dQ1$$eT1
000118821 593__ $$aPharmaceutical Science$$c2022$$dQ1
000118821 594__ $$a10.5$$b2022
000118821 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000118821 700__ $$0(orcid)0000-0002-1505-498X$$aYus Argón, C.$$uUniversidad de Zaragoza
000118821 700__ $$0(orcid)0000-0003-1599-8216$$aLanda Baila, G.$$uUniversidad de Zaragoza
000118821 700__ $$aMendoza, G.
000118821 700__ $$0(orcid)0000-0003-3165-0156$$aArruebo Gordo, M.$$uUniversidad de Zaragoza
000118821 700__ $$0(orcid)0000-0002-2966-9088$$aIrusta Alderete, S.$$uUniversidad de Zaragoza
000118821 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química
000118821 7102_ $$15005$$2790$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Tecnologi. Medio Ambiente
000118821 773__ $$g624 (2022), 122003 [11 pp]$$pInt. j. pharm.$$tInternational Journal of Pharmaceutics$$x0378-5173
000118821 8564_ $$s5157851$$uhttps://zaguan.unizar.es/record/118821/files/texto_completo.pdf$$yVersión publicada
000118821 8564_ $$s2507312$$uhttps://zaguan.unizar.es/record/118821/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000118821 909CO $$ooai:zaguan.unizar.es:118821$$particulos$$pdriver
000118821 951__ $$a2024-03-18-14:44:37
000118821 980__ $$aARTICLE