000118823 001__ 118823
000118823 005__ 20240319081007.0
000118823 0247_ $$2doi$$a10.1186/s12885-022-09990-7
000118823 0248_ $$2sideral$$a130022
000118823 037__ $$aART-2022-130022
000118823 041__ $$aeng
000118823 100__ $$aEsteva, M.
000118823 245__ $$aRelationship between time from symptom''s onset to diagnosis and prognosis in patients with symptomatic colorectal cancer
000118823 260__ $$c2022
000118823 5060_ $$aAccess copy available to the general public$$fUnrestricted
000118823 5203_ $$aBACKGROUND: Controversy exists regarding the relationship of the outcome of patients with colorectal cancer (CRC) with the time from symptom onset to diagnosis. The aim of this study is to investigate this association, with the assumption that this relationship was nonlinear and with adjustment for multiple confounders, such as tumor grade, symptoms, or admission to an emergency department. METHODS: This multicenter study with prospective follow-up was performed in five regions of Spain from 2010 to 2012. Symptomatic cases of incident CRC from a previous study were examined. At the time of diagnosis, each patient was interviewed, and the associated hospital and clinical records were reviewed. During follow-up, the clinical records were reviewed again to assess survival. Cox survival analysis with a restricted cubic spline was used to model overall and CRC-specific survival, with adjustment for variables related to the patient, health service, and tumor. RESULTS: A total of 795 patients had symptomatic CRC and 769 of them had complete data on diagnostic delay and survival. Univariate analysis indicated a lower HR for death in patients who had diagnostic intervals less than 4.2 months. However, after adjustment for variables related to the patient, tumor, and utilized health service, there was no relationship of the diagnostic delay with survival of patients with colon and rectal cancer, colon cancer alone, or rectal cancer alone. Cubic spline analysis indicated an inverse association of the diagnostic delay with 5-year survival. However, this association was not statistically significant. CONCLUSIONS: Our results indicated that the duration of diagnostic delay had no significant effect on the outcome of patients with CRC. We suggest that the most important determinant of the duration of diagnostic delay is the biological profile of the tumor. However, it remains the responsibility of community health centers and authorities to minimize diagnostic delays in patients with CRC and to implement initiatives that improve early diagnosis and provide better outcomes. © 2022. The Author(s).
000118823 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000118823 590__ $$a3.8$$b2022
000118823 592__ $$a1.137$$b2022
000118823 591__ $$aONCOLOGY$$b109 / 241 = 0.452$$c2022$$dQ2$$eT2
000118823 593__ $$aGenetics$$c2022$$dQ1
000118823 593__ $$aOncology$$c2022$$dQ2
000118823 593__ $$aCancer Research$$c2022$$dQ2
000118823 594__ $$a6.8$$b2022
000118823 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000118823 700__ $$aLeiva, A.
000118823 700__ $$aRamos-Monserrat, M.
000118823 700__ $$aEspí, A.
000118823 700__ $$aGonzález-Luján, L.
000118823 700__ $$aMacià, F.
000118823 700__ $$aMurta-Nascimento, C.
000118823 700__ $$0(orcid)0000-0001-8756-114X$$aSánchez-Calavera, M. A.$$uUniversidad de Zaragoza
000118823 700__ $$0(orcid)0000-0002-5494-6550$$aMagallón Botaya, R.$$uUniversidad de Zaragoza
000118823 700__ $$aBalboa-Barreiro, V.
000118823 700__ $$aSeoane-Pillado, T.
000118823 700__ $$aPertega-Díaz, S.
000118823 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000118823 773__ $$g22, 1 (2022), 910 [13 pp]$$pBMC CANCER$$tBMC CANCER$$x1471-2407
000118823 8564_ $$s1179401$$uhttps://zaguan.unizar.es/record/118823/files/texto_completo.pdf$$yVersión publicada
000118823 8564_ $$s2428677$$uhttps://zaguan.unizar.es/record/118823/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000118823 909CO $$ooai:zaguan.unizar.es:118823$$particulos$$pdriver
000118823 951__ $$a2024-03-18-14:44:51
000118823 980__ $$aARTICLE