000118860 001__ 118860
000118860 005__ 20241024130536.0
000118860 0247_ $$2doi$$a10.1016/j.physbeh.2022.113883
000118860 0248_ $$2sideral$$a129678
000118860 037__ $$aART-2022-129678
000118860 041__ $$aeng
000118860 100__ $$aRódenas-González, F.
000118860 245__ $$aCognitive profile of male mice exposed to a Ketogenic Diet; 35716801
000118860 260__ $$c2022
000118860 5060_ $$aAccess copy available to the general public$$fUnrestricted
000118860 5203_ $$aIn recent years, nutritional interventions for different psychiatric diseases have gained increasing attention, such as the ketogenic diet (KD). This has led to positive effects in neurological disorders such as Parkinson''s disease, addiction, autism or epilepsy. The neurobiological mechanisms through which these effects are induced and the effects in cognition still warrant investigation, and considering that other high-fat diets (HFD) can lead to cognitive disturbances that may affect the results achieved, the main aim of the present work was to evaluate the effects of a KD to determine whether it can induce such cognitive effects. A total of 30 OF1 male mice were employed to establish the behavioral profile of mice fed a KD by testing anxiety behavior (Elevated Plus Maze), locomotor activity (Open Field), learning (Hebb Williams Maze), and memory (Passive Avoidance Test). The results revealed that the KD did not affect locomotor activity, memory or hippocampal-dependent learning, as similar results were obtained with mice on a standard diet, albeit with increased anxiety behavior. We conclude that a KD is a promising nutritional approach to apply in research studies, given that it does not cause cognitive alterations.
000118860 536__ $$9info:eu-repo/grantAgreement/ES/MICINN/PID2020-112672RB-100/AEI-10.13039/501100011033
000118860 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000118860 590__ $$a2.9$$b2022
000118860 592__ $$a0.753$$b2022
000118860 591__ $$aPSYCHOLOGY, BIOLOGICAL$$b5 / 14 = 0.357$$c2022$$dQ2$$eT2
000118860 593__ $$aExperimental and Cognitive Psychology$$c2022$$dQ2
000118860 591__ $$aBEHAVIORAL SCIENCES$$b17 / 52 = 0.327$$c2022$$dQ2$$eT1
000118860 593__ $$aBehavioral Neuroscience$$c2022$$dQ2
000118860 594__ $$a6.3$$b2022
000118860 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000118860 700__ $$0(orcid)0000-0001-5990-1266$$aBlanco-Gandía, M.C.$$uUniversidad de Zaragoza
000118860 700__ $$aMiñarro, J.
000118860 700__ $$aRodríguez-Arias, M.
000118860 7102_ $$14009$$2735$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicolog.Evolut.Educac
000118860 773__ $$g254 (2022), 113883 [9 pp.]$$pPhysiol. behav.$$tPhysiology and Behavior$$x0031-9384
000118860 8564_ $$s1177918$$uhttps://zaguan.unizar.es/record/118860/files/texto_completo.pdf$$yVersión publicada
000118860 8564_ $$s2567299$$uhttps://zaguan.unizar.es/record/118860/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000118860 909CO $$ooai:zaguan.unizar.es:118860$$particulos$$pdriver
000118860 951__ $$a2024-10-24-13:01:44
000118860 980__ $$aARTICLE