118860 20241024130536.0 doi 10.1016/j.physbeh.2022.113883 sideral 129678 ART-2022-129678 eng Ródenas-González, F. Cognitive profile of male mice exposed to a Ketogenic Diet; 35716801 2022 Access copy available to the general public Unrestricted In recent years, nutritional interventions for different psychiatric diseases have gained increasing attention, such as the ketogenic diet (KD). This has led to positive effects in neurological disorders such as Parkinson''s disease, addiction, autism or epilepsy. The neurobiological mechanisms through which these effects are induced and the effects in cognition still warrant investigation, and considering that other high-fat diets (HFD) can lead to cognitive disturbances that may affect the results achieved, the main aim of the present work was to evaluate the effects of a KD to determine whether it can induce such cognitive effects. A total of 30 OF1 male mice were employed to establish the behavioral profile of mice fed a KD by testing anxiety behavior (Elevated Plus Maze), locomotor activity (Open Field), learning (Hebb Williams Maze), and memory (Passive Avoidance Test). The results revealed that the KD did not affect locomotor activity, memory or hippocampal-dependent learning, as similar results were obtained with mice on a standard diet, albeit with increased anxiety behavior. We conclude that a KD is a promising nutritional approach to apply in research studies, given that it does not cause cognitive alterations. info:eu-repo/grantAgreement/ES/MICINN/PID2020-112672RB-100/AEI-10.13039/501100011033 info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 2.9 2022 PSYCHOLOGY, BIOLOGICAL 5 / 14 = 0.357 2022 Q2 T2 BEHAVIORAL SCIENCES 17 / 52 = 0.327 2022 Q2 T1 0.753 2022 Experimental and Cognitive Psychology 2022 Q2 Behavioral Neuroscience 2022 Q2 6.3 2022 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Blanco-Gandía, M.C. Universidad de Zaragoza (orcid)0000-0001-5990-1266 Miñarro, J. Rodríguez-Arias, M. 4009 735 Universidad de Zaragoza Dpto. Psicología y Sociología Área Psicolog.Evolut.Educac 254 (2022), 113883 [9 pp.] Physiol. behav. Physiology and Behavior 0031-9384 1177918 http://zaguan.unizar.es/record/118860/files/texto_completo.pdf Versión publicada 2567299 http://zaguan.unizar.es/record/118860/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:118860 articulos driver 2024-10-24-13:01:44 ARTICLE