000118884 001__ 118884
000118884 005__ 20230519145532.0
000118884 0247_ $$2doi$$a10.1039/d1ja00155h
000118884 0248_ $$2sideral$$a126862
000118884 037__ $$aART-2021-126862
000118884 041__ $$aeng
000118884 100__ $$aGarcía-Poyo M.C.
000118884 245__ $$aDetermination of Cu in blood: Via direct analysis of dried blood spots using high-resolution continuum source graphite furnace atomic absorption spectrometry
000118884 260__ $$c2021
000118884 5060_ $$aAccess copy available to the general public$$fUnrestricted
000118884 5203_ $$aThe performance of state-of-the-art high-resolution continuum source graphite furnace atomic absorption spectrometry (HR CS GFAAS) instrumentation and four novel devices to produce dried blood spots of perfectly defined volumes is evaluated with the aim of developing a simple, direct method for the determination of Cu in blood samples. In all cases, it is feasible to obtain accurate quantitative information using any of the four devices tested (Mitra, HemaXis DB10, Capitainer qDBS and HemaPEN) via simple external calibration with aqueous standards. One of the main differences in the performance of such devices is related to the blanks obtained, such that HemaXis DB10 and HemaPEN are preferred when abnormally low Cu levels (500 µg L-1 or lower), associated with some diseases, need to be determined. The results prove that accurate values with RSD values below 10% can be achieved for these devices even for such Cu levels, while for Capitainer qDBS and, to a higher extent, for Mitra, blank variations will ultimately increase the uncertainty. It is important to stress that analysis of four real samples using both venipuncture and all the DBS specimens showed a very good agreement. Thus, the approach proposed could be readily applied, such that patients with disorders requiring Cu control can prepare their own samples and submit them via postal mail to labs for HR CS GFAAS direct and fast analysis. © The Royal Society of Chemistry.
000118884 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FEDER/Construyendo Europa desde Aragón$$9info:eu-repo/grantAgreement/ES/FEDER/Interreg POCTEFA 176-16-DBS$$9info:eu-repo/grantAgreement/ES/MCIU-AEI-FEDER/PGC2018-093753-B-I00
000118884 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000118884 590__ $$a4.351$$b2021
000118884 591__ $$aSPECTROSCOPY$$b7 / 43 = 0.163$$c2021$$dQ1$$eT1
000118884 591__ $$aCHEMISTRY, ANALYTICAL$$b23 / 87 = 0.264$$c2021$$dQ2$$eT1
000118884 592__ $$a0.795$$b2021
000118884 593__ $$aSpectroscopy$$c2021$$dQ1
000118884 593__ $$aAnalytical Chemistry$$c2021$$dQ1
000118884 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000118884 700__ $$aPécheyran C.
000118884 700__ $$aRello L.
000118884 700__ $$aGarcía-González E.
000118884 700__ $$aAlonso Rodríguez S.
000118884 700__ $$0(orcid)0000-0001-7087-9901$$aVenancio Nakadi F.$$uUniversidad de Zaragoza
000118884 700__ $$0(orcid)0000-0002-3916-9992$$aAramendía M.$$uUniversidad de Zaragoza
000118884 700__ $$0(orcid)0000-0002-7450-8769$$aResano M.$$uUniversidad de Zaragoza
000118884 7102_ $$12009$$2750$$aUniversidad de Zaragoza$$bDpto. Química Analítica$$cÁrea Química Analítica
000118884 773__ $$g36, 8 (2021), 1666-1677$$pJ. anal. at. spectrom.$$tJournal of Analytical Atomic Spectrometry$$x0267-9477
000118884 8564_ $$s7529869$$uhttps://zaguan.unizar.es/record/118884/files/texto_completo.pdf$$yPostprint
000118884 8564_ $$s1206651$$uhttps://zaguan.unizar.es/record/118884/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000118884 909CO $$ooai:zaguan.unizar.es:118884$$particulos$$pdriver
000118884 951__ $$a2023-05-18-15:31:33
000118884 980__ $$aARTICLE