000118912 001__ 118912
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000118912 0247_ $$2doi$$a10.3389/fchem.2022.977317
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000118912 037__ $$aART-2022-130029
000118912 041__ $$aeng
000118912 100__ $$aAureliano, M.
000118912 245__ $$aEditorial: Emerging polyoxometalates with biological, biomedical, and health applications
000118912 260__ $$c2022
000118912 5060_ $$aAccess copy available to the general public$$fUnrestricted
000118912 5203_ $$aThe biomedical application of metals, including platinum (Pt), lithium (Li), tungstate (W), gold (Au) or vanadium (V), among others, has become an important and a rapidly growing branch of science (Bertinat et al., 2018; Yeo et al., 2018; Vosahlikova et al., 2020; Scibior et al., 2020; Silva et al., 2021; Pena et al., 2022; Ochoa, 2022). Besides the well-characterized platinum drugs, bio-active metal-based complexes and clusters, such as gold compounds and polyoxometalates (POMs), as well as metal-based nanoparticles have shown demonstrable anti-cancer, anti-viral and anti-bacterial activities (Bertinat et al., 2018; Yeo et al., 2018; Soria-Carrera et al., 2020; Vosahlikova et al., 2020; Scibior et al., 2020; Silva et al., 2021; Aureliano et al., 2022a; Pena et al., 2022; Ochoa, 2022; Soria-Carrera et al., 2022). The biological and biomedical application of POMs–in the form of cluster ions, hybrid materials, and POM-based nanoparticles - has tripled in the last decade (Pimpão et al., 2020). In fact, the wide range of POMs uses in medicine may be due to the modulation of several proteins such as aquoporins and P-type ATPases (Gumerova et al., 2018; Fraqueza et al., 2019) although many other biomolecular and biochemical processes are affected by POMs, as illustrated by the well-studied polyoxovanadates (POVs) (Bijelic et al., 2018; Bijelic et al., 2019; Colovic et al., 2020; Aureliano et al., 2021; Aureliano et al., 2022b). POMs against bacteria and in cancer therapy and diagnostics, their modes of action, protein targets and future perspectives were recently reviewed and highlighted (Bijelic et al., 2018; Gumerova et al., 2018; Bijelic et al., 2019; Fraqueza et al., 2019; Colovic et al., 2020; Aureliano et al., 2021; Aureliano et al., 2022b). The majority of the biomedical studies have addressed how POMs affect cancer and bacterial cell growth, not to mention their antiviral activity (Bijelic et al., 2018; Fraqueza et al., 2019; Guedes et al., 2020; Colovic et al., 2020; Aureliano et al., 2021; Aureliano, 2022; Aureliano et al., 2022b), however, much remains to be understood concerning the biochemical mechanism of action of these compounds (Bijelic et al., 2018; Bijelic et al., 2019; Pimpão et al., 2020; Colovic et al., 2020; Aureliano et al., 2021; Aureliano et al., 2022b). The isopolyoxovanadate decavanadate [V10O28]6-, {V10}, is perhaps the most widely studied POM in biology, showing several roles in key biochemical and cellular processes (Crans et al., 2004; Aureliano, 2009; Aureliano and Crans, 2009; Aureliano et al., 2013; Bijelic et al., 2018; Bijelic et al., 2019; Colovic et al., 2020; Aureliano et al., 2021; Sciortino et al., 2021; Aureliano et al., 2022b). Particularly interesting under the topic of POMs speciation (Gumerova and Rompel, 2020), was the observation that {V10} binding to G-actin inhibits its polymerization to F-actin while it prevents {V10} decomposition (Ramos et al., 2006). The V10/G-actin interaction might interfere with cytoskeleton dynamics and inducing cell morphology changes (Ramos et al., 2006; Sciortino et al., 2021)...
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000118912 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b55 / 178 = 0.309$$c2022$$dQ2$$eT1
000118912 593__ $$aChemistry (miscellaneous)$$c2022$$dQ1
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000118912 655_4 $$ainfo:eu-repo/semantics/other$$vinfo:eu-repo/semantics/publishedVersion
000118912 700__ $$0(orcid)0000-0003-4848-414X$$aMitchell, S. G.
000118912 700__ $$aYin, P.
000118912 773__ $$g10 (2022), 977317 [4 pp.]$$pFront. chem.$$tFrontiers in Chemistry$$x2296-2646
000118912 8564_ $$s742791$$uhttps://zaguan.unizar.es/record/118912/files/texto_completo.pdf$$yVersión publicada
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000118912 951__ $$a2024-03-18-14:45:18
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