000118928 001__ 118928
000118928 005__ 20240319081008.0
000118928 0247_ $$2doi$$a10.1103/PhysRevE.106.024402
000118928 0248_ $$2sideral$$a130043
000118928 037__ $$aART-2022-130043
000118928 041__ $$aeng
000118928 100__ $$0(orcid)0000-0002-8089-343X$$aBarrio, R.$$uUniversidad de Zaragoza
000118928 245__ $$aDynamical mechanism for generation of arrhythmogenic early afterdepolarizations in cardiac myocytes: insights from in silico electrophysiological models
000118928 260__ $$c2022
000118928 5060_ $$aAccess copy available to the general public$$fUnrestricted
000118928 5203_ $$aWe analyze the dynamical mechanisms underlying the formation of arrhythmogenic early afterdepolarizations (EADs) in two mathematical models of cardiac cellular electrophysiology: the Sato et al. biophysically detailed model of a rabbit ventricular myocyte of dimension 27 and a reduced version of the Luo-Rudy mammalian myocyte model of dimension 3. Based on a comparison of the two models, with detailed bifurcation analysis using spike-counting techniques and continuation methods in the simple model and numerical explorations in the complex model, we locate the point where the first EAD originates in an unstable branch of periodic orbits. These results serve as a basis to propose a conjectured scheme involving a hysteresis mechanism with the creation of alternans and EADs in the unstable branch. This theoretical scheme fits well with electrophysiological experimental data on EAD generation and hysteresis phenomena. Our findings open the door to the development of novel methods for pro-arrhythmia risk prediction related to EAD generation without actual induction of EADs.
000118928 536__ $$9info:eu-repo/grantAgreement/ES/AEI/PID2021-122961NB-I00$$9info:eu-repo/grantAgreement/ES/DGA-FEDER/E24-17R$$9info:eu-repo/grantAgreement/ES/DGA-FSE/T39-20R-BSICoS group$$9info:eu-repo/grantAgreement/ES/DGA/LMP124-18$$9info:eu-repo/grantAgreement/ES/DGA/LMP94_21$$9info:eu-repo/grantAgreement/EC/H2020/638284/EU/Is your heart aging well? A systems biology approach to characterize cardiac aging from the cell to the body surface/MODELAGE$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 638284-MODELAGE$$9info:eu-repo/grantAgreement/ES/MICINN/PGC2018-096026-B-I00$$9info:eu-repo/grantAgreement/ES/MICINN-FEDER/PID2019-105674RB-I00
000118928 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000118928 590__ $$a2.4$$b2022
000118928 592__ $$a0.819$$b2022
000118928 591__ $$aPHYSICS, MATHEMATICAL$$b11 / 56 = 0.196$$c2022$$dQ1$$eT1
000118928 593__ $$aCondensed Matter Physics$$c2022$$dQ1
000118928 591__ $$aPHYSICS, FLUIDS & PLASMAS$$b17 / 34 = 0.5$$c2022$$dQ2$$eT2
000118928 593__ $$aStatistics and Probability$$c2022$$dQ2
000118928 593__ $$aStatistical and Nonlinear Physics$$c2022$$dQ2
000118928 594__ $$a4.6$$b2022
000118928 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000118928 700__ $$0(orcid)0000-0002-7374-3222$$aMartínez, M. A.$$uUniversidad de Zaragoza
000118928 700__ $$0(orcid)0000-0002-5701-1670$$aSerrano, S.$$uUniversidad de Zaragoza
000118928 700__ $$0(orcid)0000-0002-1960-407X$$aPueyo, E.$$uUniversidad de Zaragoza
000118928 7102_ $$12005$$2595$$aUniversidad de Zaragoza$$bDpto. Matemática Aplicada$$cÁrea Matemática Aplicada
000118928 7102_ $$15008$$2800$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Teoría Señal y Comunicac.
000118928 773__ $$g106, 2 (2022), 024402 [8 pp.]$$pPhys. rev., E$$tPhysical Review E$$x2470-0045
000118928 8564_ $$s5414308$$uhttps://zaguan.unizar.es/record/118928/files/texto_completo.pdf$$yVersión publicada
000118928 8564_ $$s2970885$$uhttps://zaguan.unizar.es/record/118928/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000118928 909CO $$ooai:zaguan.unizar.es:118928$$particulos$$pdriver
000118928 951__ $$a2024-03-18-14:52:02
000118928 980__ $$aARTICLE