000118931 001__ 118931
000118931 005__ 20240319081009.0
000118931 0247_ $$2doi$$a10.1016/j.mtcomm.2022.104101
000118931 0248_ $$2sideral$$a130049
000118931 037__ $$aART-2022-130049
000118931 041__ $$aeng
000118931 100__ $$aRynkevic, R.
000118931 245__ $$aCharacterisation of polycaprolactone scaffolds made by melt electrospinning writing for pelvic organ prolapse correction - a pilot study
000118931 260__ $$c2022
000118931 5060_ $$aAccess copy available to the general public$$fUnrestricted
000118931 5203_ $$aAdditive manufacturing and 3D printing technologies enable personalised treatments using custom-made prosthetics, implants and other medical devices. This research aimed to characterise novel biodegradable polycaprolactone (PCL) implants for pelvic organ prolapse repair, produced using melt electrospinning technology. PCL mesh filaments were printed in 5 configurations: 240 µm, 160 µm, three layers of 80 µm, two layers of 80 µm and one layer of 80 µm. Material sterilisation, degradation, mechanical behaviour, and geometric variation due to applied loads were studied. Polypropylene (PP) Restorelle mesh was used as a reference in this study and vaginal tissue as a baseline. Sterilisation by UV irradiation+ EtOH 70% did not affect the specimens. A significant weight loss was observed in 80 µm deposited fibers at 90 - and 180 - days of degradation, losing 10% of weight in neutral solution to 27% in acidic. All printed PCL deposited fibers had functional loss at 180 - day degradation in acidic solution (pH 4.2) (p < 0.05). PCL printed meshes were classified as ultra-lightweight, except lightweight 240 µm filament mesh. PCL meshes closely match the biomechanical properties of vaginal tissues, particularly in the comfort zone, unlike the Restorelle implant. The 3D printed mesh pores appeared to be stable compared to those of Restorelle meshes that had been used clinically until the FDA pulled its approval. Based on the pilot study results, improved implant designs will be studied, and in vitro experiments on the cell adhesion and growth response will be conducted.
000118931 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000118931 590__ $$a3.8$$b2022
000118931 592__ $$a0.644$$b2022
000118931 591__ $$aMATERIALS SCIENCE, MULTIDISCIPLINARY$$b153 / 343 = 0.446$$c2022$$dQ2$$eT2
000118931 593__ $$aMaterials Chemistry$$c2022$$dQ2
000118931 593__ $$aMechanics of Materials$$c2022$$dQ2
000118931 593__ $$aMaterials Science (miscellaneous)$$c2022$$dQ2
000118931 594__ $$a4.1$$b2022
000118931 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000118931 700__ $$aSilva, M. E. T.
000118931 700__ $$0(orcid)0000-0001-9732-4498$$aMartins, P.
000118931 700__ $$aMascarenhas, T.
000118931 700__ $$aAlves, J. L.
000118931 700__ $$aFernandes, A. A.
000118931 773__ $$g32 (2022), 104101 [9 pp.]$$tMaterials Today Communications$$x2352-4928
000118931 8564_ $$s9247123$$uhttps://zaguan.unizar.es/record/118931/files/texto_completo.pdf$$yPostprint
000118931 8564_ $$s2552729$$uhttps://zaguan.unizar.es/record/118931/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000118931 909CO $$ooai:zaguan.unizar.es:118931$$particulos$$pdriver
000118931 951__ $$a2024-03-18-14:55:03
000118931 980__ $$aARTICLE