118954 20240319081010.0 doi 10.1021/acs.joc.2c00947 sideral 130090 ART-2022-130090 eng Canudo-Barreras, G. Universidad de Zaragoza (orcid)0000-0003-1732-9155 Gold-catalyzed 1, 3-Thiazine formation and uncommon tautomer isolation 2022 Access copy available to the general public Unrestricted This work represents the first example of a gold-catalyzed formation of 1, 3-thiazine/1, 3-thiazinane by means of a catalytic approach and further uncommon isolation of the two tautomers. The developed protocol gives rise to a broad scope of 1, 3-thiazine derivatives with excellent yields in short reaction times. Interestingly, different isomers could be obtained depending on the state of the compound, and in the crystal state the 1, 3-thiazinane isomer is obtained, while in solution the 1, 3-thiazine is the unique isomer. This work represents an interesting approach for the synthesis of potential biologically relevant molecules and a crucial precedent in tautomerism isolation and characterization. © 2022 American Chemical Society. All rights reserved. info:eu-repo/grantAgreement/ES/DGA-FSE/E07-20R info:eu-repo/grantAgreement/ES/MCIN/AEI/PID2020-117455GB-I00 info:eu-repo/grantAgreement/ES/MICINN/PID2019-104379RB-C21-AEI-10.13039-501100011033 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 3.6 2022 CHEMISTRY, ORGANIC 10 / 52 = 0.192 2022 Q1 T1 0.892 2022 Organic Chemistry 2022 Q1 6.8 2022 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Salvador, D. Herrera, R. P. Gimeno, M. C. (orcid)0000-0003-0553-0695 2000 655 Universidad de Zaragoza Dpto. Ciencias de la Tierra Área Paleontología 87, 16 (2022), 10747-10754 J. org. chem. Journal of Organic Chemistry 0022-3263 2430765 http://zaguan.unizar.es/record/118954/files/texto_completo.pdf Versión publicada 2400432 http://zaguan.unizar.es/record/118954/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:118954 articulos driver 2024-03-18-15:04:14 ARTICLE