000118976 001__ 118976
000118976 005__ 20240319081013.0
000118976 0247_ $$2doi$$a10.1177/03009858221109095
000118976 0248_ $$2sideral$$a130161
000118976 037__ $$aART-2022-130161
000118976 041__ $$aeng
000118976 100__ $$0(orcid)0000-0003-3792-287X$$aHeras, Marcelo de las$$uUniversidad de Zaragoza
000118976 245__ $$aChronic pithomycotoxicosis associated with obstructive rhinopathy in sheep
000118976 260__ $$c2022
000118976 5060_ $$aAccess copy available to the general public$$fUnrestricted
000118976 5203_ $$aPithomycotoxicosis (facial eczema) is a seasonal hepatogenous photosensitization of sheep caused by the ingestion of sporidesmin contained in the spores of the fungus Pithomyces chartarum. We describe 4 cases of obstructive rhinopathy associated with chronic pithomycotoxicosis naturally occurring in the north of Spain. Sheep were 5 to 7 years old and Latxa breed. A detailed clinical study was conducted together with computerized tomography examination and completed by necropsy and histopathology. All sheep developed a permanent narrowing of the nasal lumen close to the nostrils causing inspiratory dyspnea and snoring. Computerized tomography demonstrated a significant increase of soft tissue in the rostral nasal cavity. Elevated gamma-glutamyl transferase, alanine aminotransferase, and lipase were noted on serum biochemistry. At necropsy, liver atrophy and fibrosis associated with chronic pithomycotoxicosis was identified in 3 of the sheep. All sheep had whitish elevations and rough surfaces on the alar folds and areas adjacent to the nasal surfaces. Histopathologic assessments, which included histochemical and immunohistochemical techniques, of the nasal lesions identified moderate to severe arteriosclerosis in 21.5% to 61.9% of the small arteries evaluated with surrounding fibrosis and edema. No changes associated with hypersensitivity reactions were found. These lesions were similar to the ones described in blood vessels of the liver in chronic pithomycotoxicosis and in our cases. The results of this study suggest a direct action of the sporidesmin on the rostral nasal cavity. Further studies are needed to analyze the impact of the sporidesmin on the sheep nasal mucosa.
000118976 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000118976 590__ $$a2.4$$b2022
000118976 592__ $$a0.609$$b2022
000118976 591__ $$aVETERINARY SCIENCES$$b29 / 144 = 0.201$$c2022$$dQ1$$eT1
000118976 593__ $$aVeterinary (miscellaneous)$$c2022$$dQ1
000118976 591__ $$aPATHOLOGY$$b41 / 76 = 0.539$$c2022$$dQ3$$eT2
000118976 594__ $$a4.4$$b2022
000118976 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000118976 700__ $$0(orcid)0000-0002-7822-6646$$aLacasta, Delia$$uUniversidad de Zaragoza
000118976 700__ $$aReséndiz, Raúl A.
000118976 700__ $$aRivas, Ane
000118976 700__ $$aGarzianda, Ane
000118976 700__ $$aMiguel, Ricardo de
000118976 700__ $$0(orcid)0000-0002-8474-2831$$aRuiz, Héctor$$uUniversidad de Zaragoza
000118976 700__ $$aCastells, Enrique
000118976 700__ $$0(orcid)0000-0002-2535-6914$$aGonzález, Vicente$$uUniversidad de Zaragoza
000118976 700__ $$0(orcid)0000-0003-0042-8800$$aFerrer, Luis M.$$uUniversidad de Zaragoza
000118976 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal
000118976 7102_ $$11009$$2617$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Medicina y Cirugía Animal
000118976 7102_ $$15011$$2063$$aUniversidad de Zaragoza$$bDpto. CC.Agrar.y Medio Natural$$cÁrea Botánica
000118976 773__ $$g59, 6 (2022), 950-959$$pVet. pathol.$$tVeterinary Pathology$$x0300-9858
000118976 8564_ $$s3035992$$uhttps://zaguan.unizar.es/record/118976/files/texto_completo.pdf$$yVersión publicada
000118976 8564_ $$s2885625$$uhttps://zaguan.unizar.es/record/118976/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000118976 909CO $$ooai:zaguan.unizar.es:118976$$particulos$$pdriver
000118976 951__ $$a2024-03-18-15:17:48
000118976 980__ $$aARTICLE