118976 20240319081013.0 doi 10.1177/03009858221109095 sideral 130161 ART-2022-130161 eng Heras, Marcelo de las Universidad de Zaragoza (orcid)0000-0003-3792-287X Chronic pithomycotoxicosis associated with obstructive rhinopathy in sheep 2022 Access copy available to the general public Unrestricted Pithomycotoxicosis (facial eczema) is a seasonal hepatogenous photosensitization of sheep caused by the ingestion of sporidesmin contained in the spores of the fungus Pithomyces chartarum. We describe 4 cases of obstructive rhinopathy associated with chronic pithomycotoxicosis naturally occurring in the north of Spain. Sheep were 5 to 7 years old and Latxa breed. A detailed clinical study was conducted together with computerized tomography examination and completed by necropsy and histopathology. All sheep developed a permanent narrowing of the nasal lumen close to the nostrils causing inspiratory dyspnea and snoring. Computerized tomography demonstrated a significant increase of soft tissue in the rostral nasal cavity. Elevated gamma-glutamyl transferase, alanine aminotransferase, and lipase were noted on serum biochemistry. At necropsy, liver atrophy and fibrosis associated with chronic pithomycotoxicosis was identified in 3 of the sheep. All sheep had whitish elevations and rough surfaces on the alar folds and areas adjacent to the nasal surfaces. Histopathologic assessments, which included histochemical and immunohistochemical techniques, of the nasal lesions identified moderate to severe arteriosclerosis in 21.5% to 61.9% of the small arteries evaluated with surrounding fibrosis and edema. No changes associated with hypersensitivity reactions were found. These lesions were similar to the ones described in blood vessels of the liver in chronic pithomycotoxicosis and in our cases. The results of this study suggest a direct action of the sporidesmin on the rostral nasal cavity. Further studies are needed to analyze the impact of the sporidesmin on the sheep nasal mucosa. info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 2.4 2022 VETERINARY SCIENCES 29 / 144 = 0.201 2022 Q1 T1 PATHOLOGY 41 / 76 = 0.539 2022 Q3 T2 0.609 2022 Veterinary (miscellaneous) 2022 Q1 4.4 2022 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Lacasta, Delia Universidad de Zaragoza (orcid)0000-0002-7822-6646 Reséndiz, Raúl A. Rivas, Ane Garzianda, Ane Miguel, Ricardo de Ruiz, Héctor Universidad de Zaragoza (orcid)0000-0002-8474-2831 Castells, Enrique González, Vicente Universidad de Zaragoza (orcid)0000-0002-2535-6914 Ferrer, Luis M. Universidad de Zaragoza (orcid)0000-0003-0042-8800 1009 773 Universidad de Zaragoza Dpto. Patología Animal Área Sanidad Animal 1009 617 Universidad de Zaragoza Dpto. Patología Animal Área Medicina y Cirugía Animal 5011 063 Universidad de Zaragoza Dpto. CC.Agrar.y Medio Natural Área Botánica 59, 6 (2022), 950-959 Vet. pathol. Veterinary Pathology 0300-9858 3035992 http://zaguan.unizar.es/record/118976/files/texto_completo.pdf Versión publicada 2885625 http://zaguan.unizar.es/record/118976/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:118976 articulos driver 2024-03-18-15:17:48 ARTICLE