000118983 001__ 118983
000118983 005__ 20241125101126.0
000118983 0247_ $$2doi$$a10.1002/wnan.1844
000118983 0248_ $$2sideral$$a130173
000118983 037__ $$aART-2023-130173
000118983 041__ $$aeng
000118983 100__ $$aPaesa, Mónica$$uUniversidad de Zaragoza
000118983 245__ $$aNew insights in osteoarthritis diagnosis and treatment: Nano-strategies for an improved disease management
000118983 260__ $$c2023
000118983 5060_ $$aAccess copy available to the general public$$fUnrestricted
000118983 5203_ $$aOsteoarthritis (OA) is a common chronic joint pathology that has become a predominant cause of disability worldwide. Even though the origin and evolution of OA rely on different factors that are not yet elucidated nor understood, the development of novel strategies to treat OA has emerged in the last years. Cartilage degradation is the main hallmark of the pathology though alterations in bone and synovial inflammation, among other comorbidities, are also involved during OA progression. From a molecular point of view, a vast amount of signaling pathways are implicated in the progression of the disease, opening up a wide plethora of targets to attenuate or even halt OA. The main purpose of this review is to shed light on the recent strategies published based on nanotechnology for the early diagnosis of the disease as well as the most promising nano-enabling therapeutic approaches validated in preclinical models. To address the clinical issue, the key pathways involved in OA initiation and progression are described as the main potential targets for OA prevention and early treatment. Furthermore, an overview of current therapeutic strategies is depicted. Finally, to solve the drawbacks of current treatments, nanobiomedicine has shown demonstrated benefits when using drug delivery systems compared with the administration of the equivalent doses of the free drugs and the potential of disease-modifying OA drugs when using nanosystems. We anticipate that the development of smart and specific bioresponsive and biocompatible nanosystems will provide a solid and promising basis for effective OA early diagnosis and treatment.
000118983 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII-IIS/MS19-00092
000118983 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000118983 590__ $$a6.9$$b2023
000118983 592__ $$a1.571$$b2023
000118983 591__ $$aNANOSCIENCE & NANOTECHNOLOGY$$b33 / 141 = 0.234$$c2023$$dQ1$$eT1
000118983 593__ $$aBioengineering$$c2023$$dQ1
000118983 591__ $$aMEDICINE, RESEARCH & EXPERIMENTAL$$b22 / 189 = 0.116$$c2023$$dQ1$$eT1
000118983 593__ $$aNanoscience and Nanotechnology$$c2023$$dQ1
000118983 593__ $$aMedicine (miscellaneous)$$c2023$$dQ1
000118983 593__ $$aBiomedical Engineering$$c2023$$dQ1
000118983 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000118983 700__ $$0(orcid)0000-0002-9324-0446$$aAlejo, Teresa
000118983 700__ $$0(orcid)0000-0003-2587-7506$$aGarcía Álvarez, Felicito$$uUniversidad de Zaragoza
000118983 700__ $$0(orcid)0000-0003-3165-0156$$aArruebo, Manuel$$uUniversidad de Zaragoza
000118983 700__ $$0(orcid)0000-0003-2293-363X$$aMendoza, Gracia
000118983 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química
000118983 7102_ $$11013$$2830$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Traumatología y Ortopedia
000118983 773__ $$g15, 2 (2023), e1844 [35 pp.]$$pWiley interdiscip. rev. Nanomed. nanobiotechnol.$$tWILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY$$x1939-5116
000118983 8564_ $$s20240858$$uhttps://zaguan.unizar.es/record/118983/files/texto_completo.pdf$$yVersión publicada
000118983 8564_ $$s2913383$$uhttps://zaguan.unizar.es/record/118983/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000118983 909CO $$ooai:zaguan.unizar.es:118983$$particulos$$pdriver
000118983 951__ $$a2024-11-22-11:57:41
000118983 980__ $$aARTICLE