000119592 001__ 119592
000119592 005__ 20230519145525.0
000119592 0247_ $$2doi$$a10.3390/nano11113017
000119592 0248_ $$2sideral$$a126825
000119592 037__ $$aART-2021-126825
000119592 041__ $$aeng
000119592 100__ $$aD’amora M.
000119592 245__ $$aIn vitro and in vivo biocompatibility of boron/nitrogen co-doped carbon nano-onions
000119592 260__ $$c2021
000119592 5060_ $$aAccess copy available to the general public$$fUnrestricted
000119592 5203_ $$aBoron/nitrogen, co-doped, carbon nano-onions (BN-CNOs) have recently shown great promise as catalysts for the oxygen reduction reaction, due to the improved electronic properties imparted by the dopant atoms; however, the interactions of BN-CNOs with biological systems have not yet been explored. In this study, we examined the toxicological profiles of BN-CNOs and oxidized BN-CNOs (oxi-BN-CNOs) in vitro in both healthy and cancer cell lines, as well as on the embryonic stages of zebrafish (Danio rerio) in vivo. The cell viabilities of both cell lines cells were not affected after treatment with different concentrations of both doped CNO derivatives. On the other hand, the analysis of BN-CNOs and oxidized BN-CNO interactions with zebrafish embryos did not report any kind of perturbations, in agreement with the in vitro results. Our results show that both doped CNO derivatives possess a high biocompatibility and biosafety in cells and more complex systems. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
000119592 536__ $$9info:eu-repo/grantAgreement/EC/H2020/823717/EU/Enabling Science and Technology through European Electron Microscopy/ESTEEM3$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 823717-ESTEEM3
000119592 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000119592 590__ $$a5.719$$b2021
000119592 591__ $$aPHYSICS, APPLIED$$b37 / 161 = 0.23$$c2021$$dQ1$$eT1
000119592 591__ $$aMATERIALS SCIENCE, MULTIDISCIPLINARY$$b109 / 345 = 0.316$$c2021$$dQ2$$eT1
000119592 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b55 / 180 = 0.306$$c2021$$dQ2$$eT1
000119592 591__ $$aNANOSCIENCE & NANOTECHNOLOGY$$b53 / 109 = 0.486$$c2021$$dQ2$$eT2
000119592 592__ $$a0.839$$b2021
000119592 593__ $$aMaterials Science (miscellaneous)$$c2021$$dQ1
000119592 593__ $$aChemical Engineering (miscellaneous)$$c2021$$dQ1
000119592 594__ $$a6.6$$b2021
000119592 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000119592 700__ $$aCamisasca A.
000119592 700__ $$0(orcid)0000-0002-2071-9093$$aArenal R.
000119592 700__ $$aGiordani S.
000119592 773__ $$g11, 11 (2021), 3017 [13 pp]$$pNanomaterials (Basel)$$tNanomaterials$$x2079-4991
000119592 8564_ $$s3907505$$uhttps://zaguan.unizar.es/record/119592/files/texto_completo.pdf$$yVersión publicada
000119592 8564_ $$s2693279$$uhttps://zaguan.unizar.es/record/119592/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000119592 909CO $$ooai:zaguan.unizar.es:119592$$particulos$$pdriver
000119592 951__ $$a2023-05-18-15:25:44
000119592 980__ $$aARTICLE