119658 20250926150151.0 doi 10.3389/fpsyg.2021.647265 sideral 126398 ART-2021-126398 eng Crespo-Sanmiguel, I Loneliness Mediates the Relationship Between Early Life Stress and Perceived Stress but not Hypothalamic-Pituitary-Adrenal Axis Functioning 2021 Access copy available to the general public Unrestricted Many authors have proposed that early life stress (ELS) provokes a dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis and contributes negatively to the management of stress in adulthood. However, these associations have not always been observed, making it necessary to include new factors that could explain the different results found. In this regard, people with ELS experiences report less social support during adulthood, suggesting that loneliness could be a mediating factor. Thus, our aims were to investigate whether ELS was related to both perceived stress and diurnal HPA axis activity, and whether loneliness mediates these relationships, in a community sample (N=187, 18-55years old). Fourteen cortisol samples were collected on two non-consecutive days to obtain the overall diurnal cortisol, diurnal cortisol slope, and bedtime levels. Additionally, ELS was assessed with the Risky Families Questionnaire (RFQ) and the Recalled Childhood and Adolescence Perceived Stress (ReCAPS) measure. Results revealed that ELS was associated with perceived stress, but not HPA axis functioning, and loneliness mediated the relationship between ELS and perceived stress, but not between ELS and HPA axis functioning. Similar results were found for both ELS questionnaires, suggesting that the ReCAPS is an adequate tool. These results highlight the importance of loneliness in understanding the long-term effects of ELS, and they indicate different effects of ELS on subjective and physiological stress indicators. info:eu-repo/grantAgreement/ES/DGA-FEDER/Construyendo Europa desde Aragón info:eu-repo/grantAgreement/ES/DGA/S31-20D info:eu-repo/grantAgreement/ES/DIIU-DGA/European Social Fund info:eu-repo/grantAgreement/ES/MCIU/BES-2017-082148 info:eu-repo/grantAgreement/ES/MCIU/FPU17-03428 info:eu-repo/grantAgreement/ES/MCIU/PSI2016-78763-P info:eu-repo/grantAgreement/ES/MCIU/PSI2017-90806 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 4.232 2021 PSYCHOLOGY, MULTIDISCIPLINARY 35 / 146 = 0.24 2021 Q1 T1 0.873 2021 Psychology (miscellaneous) 2021 Q1 4.0 2021 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Zapater-Fajari, M Pulopulos, MM Universidad de Zaragoza (orcid)0000-0002-7048-3795 Hidalgo, V Universidad de Zaragoza (orcid)0000-0003-3920-1099 Salvador, A 4009 725 Universidad de Zaragoza Dpto. Psicología y Sociología Área Psicobiología 12 (2021), 647265 [12 pp.] Front. psychol. Frontiers in Psychology 1664-1078 716145 http://zaguan.unizar.es/record/119658/files/texto_completo.pdf Versión publicada 2239470 http://zaguan.unizar.es/record/119658/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:119658 articulos driver 2025-09-26-14:59:35 ARTICLE