000119688 001__ 119688
000119688 005__ 20240319081010.0
000119688 0247_ $$2doi$$a10.3389/fmed.2022.843074
000119688 0248_ $$2sideral$$a130074
000119688 037__ $$aART-2022-130074
000119688 041__ $$aeng
000119688 100__ $$aHernandez-Ainsa, M.$$uUniversidad de Zaragoza
000119688 245__ $$aBlood-cell-based inflammatory markers as a useful tool for early diagnosis in colorectal cancer
000119688 260__ $$c2022
000119688 5060_ $$aAccess copy available to the general public$$fUnrestricted
000119688 5203_ $$aBackground: Systemic inflammation seems to be involved in the pathogenetic pathways of colorectal cancer (CRC). Analytical markers that reflect the inflammatory status, such as neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) or systemic immune-inflammation index (SII), have been proposed as tools for the prognosis of CRC. Nevertheless, their use for diagnosis has been scarcely investigated. Aims: To analyze the ability of these markers and of a new marker combining SII and hemoglobin concentration, named NP/LHb = neutrophils x platelets]/lymphocytes x hemoglobin], as tools for CRC diagnosis. Furthermore, we studied their association with CRC-related variables. Methods: Case-control study including 214 CRC patients and 214 controls without CRC, matched by age (±5 years) and sex. We collected demographic, CRC-related and laboratory variables to calculate NLR, PLR, SII, and NP/LHb. In the case group, the laboratory variables were collected at two different period times, 6 months (IQR 4–8) before the CRC diagnosis and at the time of the diagnosis. ROC analysis was performed to evaluate the discriminatory accuracy of each index and we calculated Se, Sp, PPV, NPV, and OR to identify the diagnostic performance of each positive marker. Results: NP/LHb showed high Sp (92.06%) and PPV (87.50%) to diagnose patients with CRC. This index exhibited an OR of 14.52 (8.26–25.52) and the best area under the curve (AUC: 0.78) for a positive CRC diagnosis. We found significant differences in all indices according to the presence of CRC, observing the highest values in CRC patients at time of diagnosis, in comparison with the analysis performed in the previous months to diagnosis or with control patients. There were significant differences in all ratios according to TNM stages (p < 0.05). PLR, SII and NP/LHb (but not NLR) showed significant differences according to tumor location (p < 0.05). Right-sided colon cancers presented the highest values, in comparison with left-sided and rectal cancers. Conclusions: Systemic inflammatory cell ratios (especially NP/LHb) change over time with the development of CRC, so they could be useful in its early diagnosis. We suggest that they could be routinely measured in patients with suspicion of CRC, to identify those ones with a higher risk of cancer, considering the high positive predictive value they have shown in our study. Copyright © 2022 Hernandez-Ainsa, Velamazan, Lanas, Carrera-Lasfuentes and Piazuelo.
000119688 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B25-17R$$9info:eu-repo/grantAgreement/ES/ISCIII/CIBERehd
000119688 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000119688 590__ $$a3.9$$b2022
000119688 592__ $$a0.926$$b2022
000119688 591__ $$aMEDICINE, GENERAL & INTERNAL$$b58 / 169 = 0.343$$c2022$$dQ2$$eT2
000119688 593__ $$aMedicine (miscellaneous)$$c2022$$dQ1
000119688 594__ $$a3.6$$b2022
000119688 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000119688 700__ $$aVelamazan, R.
000119688 700__ $$0(orcid)0000-0001-5932-2889$$aLanas, A.$$uUniversidad de Zaragoza
000119688 700__ $$aCarrera-Lasfuentes, P.
000119688 700__ $$0(orcid)0000-0001-5813-3445$$aPiazuelo, E.$$uUniversidad de Zaragoza
000119688 7102_ $$11012$$2410$$aUniversidad de Zaragoza$$bDpto. Farmac.Fisiol.y Med.L.F.$$cÁrea Fisiología
000119688 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000119688 773__ $$g9 (2022), 843074 - [9 pp]$$pFront. med.$$tFrontiers in Medicine$$x2296-858X
000119688 8564_ $$s520306$$uhttps://zaguan.unizar.es/record/119688/files/texto_completo.pdf$$yVersión publicada
000119688 8564_ $$s2315403$$uhttps://zaguan.unizar.es/record/119688/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
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000119688 951__ $$a2024-03-18-15:01:03
000119688 980__ $$aARTICLE