000119713 001__ 119713 000119713 005__ 20241125101126.0 000119713 0247_ $$2doi$$a10.1111/add.16035 000119713 0248_ $$2sideral$$a130511 000119713 037__ $$aART-2023-130511 000119713 041__ $$aeng 000119713 100__ $$aMewton, L. 000119713 245__ $$aThe relationship between alcohol use and dementia in adults aged more than 60 years: a combined analysis of prospective, individual-participant data from 15 international studies 000119713 260__ $$c2023 000119713 5060_ $$aAccess copy available to the general public$$fUnrestricted 000119713 5203_ $$aMethods: Individual participant data meta-analysis of 15 prospective epidemiological cohort studies from countries situated in six continents. Cox regression investigated the dementia risk associated with alcohol use in older adults aged over 60 years. Additional analyses assessed the alcohol–dementia relationship in the sample stratified by sex and by continent. Participants included 24 478 community dwelling individuals without a history of dementia at baseline and at least one follow-up dementia assessment. The main outcome measure was all-cause dementia as determined by clinical interview. Results: At baseline, the mean age across studies was 71.8 (standard deviation = 7.5, range = 60–102 years), 14 260 (58.3%) were female and 13 269 (54.2%) were current drinkers. During 151 636 person-years of follow-up, there were 2124 incident cases of dementia (14.0 per 1000 person-years). When compared with abstainers, the risk for dementia was lower in occasional [hazard ratio (HR) = 0.78; 95% confidence interval (CI) = 0.68–0.89], light–moderate (HR = 0.78; 95% CI = 0.70–0.87) and moderate–heavy drinkers (HR = 0.62; 95% CI = 0.51–0.77). There was no evidence of differences between life-time abstainers and former drinkers in terms of dementia risk (HR = 0.98; 95% CI = 0.81–1.18). In dose–response analyses, moderate drinking up to 40 g/day was associated with a lower risk of dementia when compared with lif-time abstaining. Among current drinkers, there was no consistent evidence for differences in terms of dementia risk. Results were similar when the sample was stratified by sex. When analysed at the continent level, there was considerable heterogeneity in the alcohol–dementia relationship. Conclusions: Abstinence from alcohol appears to be associated with an increased risk for all-cause dementia. Among current drinkers, there appears to be no consistent evidence to suggest that the amount of alcohol consumed in later life is associated with dementia risk. 000119713 536__ $$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/G03-128$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/01-0255$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/03-0815$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/06-0617$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/94-1562$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/97-1321E$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/98-0103 000119713 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/ 000119713 590__ $$a5.2$$b2023 000119713 592__ $$a2.129$$b2023 000119713 591__ $$aPSYCHIATRY$$b32 / 279 = 0.115$$c2023$$dQ1$$eT1 000119713 593__ $$aPsychiatry and Mental Health$$c2023$$dQ1 000119713 591__ $$aSUBSTANCE ABUSE$$b2 / 56 = 0.036$$c2023$$dQ1$$eT1 000119713 593__ $$aMedicine (miscellaneous)$$c2023$$dQ1 000119713 591__ $$aPSYCHIATRY$$b32 / 279 = 0.115$$c2023$$dQ1$$eT1 000119713 591__ $$aSUBSTANCE ABUSE$$b2 / 56 = 0.036$$c2023$$dQ1$$eT1 000119713 594__ $$a10.8$$b2023 000119713 655_4 $$ainfo:eu-repo/semantics/review$$vinfo:eu-repo/semantics/publishedVersion 000119713 700__ $$aVisontay, R. 000119713 700__ $$aHoy, N. 000119713 700__ $$aLipnicki, D. M. 000119713 700__ $$aSunderland, M. 000119713 700__ $$aLipton, R. B. 000119713 700__ $$aGuerchet, M. 000119713 700__ $$aRitchie, K. 000119713 700__ $$aNajar, J. 000119713 700__ $$aScarmeas, N. 000119713 700__ $$aKim, K.-W. 000119713 700__ $$aRiedel Heller, S. 000119713 700__ $$aBoxtel, M. van 000119713 700__ $$aJacobsen, E. 000119713 700__ $$aBrodaty, H. 000119713 700__ $$aAnstey, K. J. 000119713 700__ $$aHaan, M. 000119713 700__ $$aScazufca, M. 000119713 700__ $$0(orcid)0000-0002-1252-2397$$aLobo, E.$$uUniversidad de Zaragoza 000119713 700__ $$aSachdev, P. S. 000119713 7102_ $$11011$$2615$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Medic.Prevent.Salud Públ. 000119713 773__ $$g118, 3 (2023), 412-424$$pAddiction$$tADDICTION$$x0965-2140 000119713 8564_ $$s568485$$uhttps://zaguan.unizar.es/record/119713/files/texto_completo.pdf$$yVersión publicada 000119713 8564_ $$s2506556$$uhttps://zaguan.unizar.es/record/119713/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000119713 909CO $$ooai:zaguan.unizar.es:119713$$particulos$$pdriver 000119713 951__ $$a2024-11-22-11:57:45 000119713 980__ $$aARTICLE