000119716 001__ 119716
000119716 005__ 20240319081014.0
000119716 0247_ $$2doi$$a10.1038/s41598-022-21144-0
000119716 0248_ $$2sideral$$a130570
000119716 037__ $$aART-2022-130570
000119716 041__ $$aeng
000119716 100__ $$aComín, Jessica
000119716 245__ $$aEstimation of the mutation rate of Mycobacterium tuberculosis in cases with recurrent tuberculosis using whole genome sequencing
000119716 260__ $$c2022
000119716 5060_ $$aAccess copy available to the general public$$fUnrestricted
000119716 5203_ $$aThe study of tuberculosis latency is problematic due to the difficulty of isolating the bacteria in the dormancy state. Despite this, several in vivo approaches have been taken to mimic the latency process. Our group has studied the evolution of the bacteria in 18 cases of recurrent tuberculosis. We found that HIV positive patients develop recurrent tuberculosis earlier, generally in the first two years (p value = 0.041). The genome of the 36 Mycobacterium tuberculosis paired isolates (first and relapsed isolates) showed that none of the SNPs found within each pair was observed more than once, indicating that they were not directly related to the recurrence process. Moreover, some IS6110 movements were found in the paired isolates, indicating the presence of different clones within the patient. Finally, our results suggest that the mutation rate remains constant during all the period as no correlation was found between the number of SNPs and the time to relapse.
000119716 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/FIS18-0336
000119716 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000119716 590__ $$a4.6$$b2022
000119716 592__ $$a0.973$$b2022
000119716 591__ $$aMULTIDISCIPLINARY SCIENCES$$b22 / 73 = 0.301$$c2022$$dQ2$$eT1
000119716 593__ $$aMultidisciplinary$$c2022$$dQ1
000119716 594__ $$a7.5$$b2022
000119716 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000119716 700__ $$aCebollada, Alberto
000119716 700__ $$0(orcid)0000-0003-2266-8602$$aIglesias, María José$$uUniversidad de Zaragoza
000119716 700__ $$aIbarz, Daniel$$uUniversidad de Zaragoza
000119716 700__ $$0(orcid)0000-0003-2044-6782$$aViñuelas, Jesús$$uUniversidad de Zaragoza
000119716 700__ $$aTorres, Luis
000119716 700__ $$aSahagún, Juan$$uUniversidad de Zaragoza
000119716 700__ $$aLafoz, María Carmen
000119716 700__ $$aEsteban de Juanas, Felipe
000119716 700__ $$aMalo, María Carmen
000119716 700__ $$0(orcid)0000-0002-3011-2519$$aSamper, Sofía$$uUniversidad de Zaragoza
000119716 700__ $$a
000119716 7102_ $$11011$$2630$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Microbiología
000119716 7102_ $$11011$$2615$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Medic.Prevent.Salud Públ.
000119716 773__ $$g12, 1 (2022), 16728 [10 pp.]$$pSci. rep. (Nat. Publ. Group)$$tScientific reports (Nature Publishing Group)$$x2045-2322
000119716 8564_ $$s1917583$$uhttps://zaguan.unizar.es/record/119716/files/texto_completo.pdf$$yVersión publicada
000119716 8564_ $$s2599934$$uhttps://zaguan.unizar.es/record/119716/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000119716 909CO $$ooai:zaguan.unizar.es:119716$$particulos$$pdriver
000119716 951__ $$a2024-03-18-15:29:41
000119716 980__ $$aARTICLE